Polygenic Score (PGS) ID: PGS003457

Predicted Trait
Reported Trait Intracerebral hemorrhage
Mapped Trait(s) intracerebral hemorrhage (EFO_0005669)
Released in PGS Catalog: March 24, 2023
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Score Details

Score Construction
PGS Name GRS_ICH
Development Method
Name LDpred2-grid
Parameters h2=0.7288, p=0.1, sparse=FALSE
Variants
Original Genome Build NR
Number of Variants 682,890
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000450
Citation (link to publication) Mayerhofer E et al. Stroke (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
3,026 individuals (100%)
Score Development/Training
European: 100%
862 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST002389
Europe PMC: 24656865
3,026 individualsEuropeanNR
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Score Development/Training
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
[
  • 431 cases
  • , 431 controls
]
,
59.0 % Male samples
EuropeanUKBCases with history of ICH at baseline and the same number of randomly selected age- and sex-matched ... ICH-free controls.Show moreMean = 60.0 yearsMean = 11.9 years
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM017258PSS010179|
Multi-ancestry (including European)|
5,530 individuals
PGP000450 |
Mayerhofer E et al. Stroke (2023)
Reported Trait: Incident intracerebral hemorrhage in anticoagulation therapyHR: 1.24 [1.01, 1.53]: 0.02age at baseline (controls) or ICH event (cases), sex, PC1 to 10, and genotyping array
PPM017259PSS010179|
Multi-ancestry (including European)|
5,530 individuals
PGP000450 |
Mayerhofer E et al. Stroke (2023)
Reported Trait: Incident intracerebral hemorrhage in anticoagulation therapyHR: 1.33 [1.11, 1.59]C-index: 0.57 [0.5, 0.64]age at baseline (controls) or ICH event (cases), sex, PC1 to 10, and genotyping array, clinical risk...  scoreShow more
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS010179The test cohort consisted of individuals without a history of ICH at baseline and anticoagulant use ... defined by self-report in the verbal interview at inclusion. Furthermore, individuals were included if they had a diagnosis of the International Classification of Diseases, Tenth Revision code Z92.1 (personal history of long-term (current) use of anticoagulants) or D68.3 (hemorrhagic disorder due to circulating anticoagulants) at baseline or a prescription of an anticoagulant medication between baseline and 6 months thereafter in the primary care dataShow moreMean = 11.9 years
[
  • 86 cases
  • , 4,972 controls
]
,
69.0 % Male samples
Mean = 62.0 yearsEuropeanUKB
PSS010179The test cohort consisted of individuals without a history of ICH at baseline and anticoagulant use ... defined by self-report in the verbal interview at inclusion. Furthermore, individuals were included if they had a diagnosis of the International Classification of Diseases, Tenth Revision code Z92.1 (personal history of long-term (current) use of anticoagulants) or D68.3 (hemorrhagic disorder due to circulating anticoagulants) at baseline or a prescription of an anticoagulant medication between baseline and 6 months thereafter in the primary care dataShow moreMean = 11.9 years
[
  • 8 cases
  • , 464 controls
]
,
69.0 % Male samples
Mean = 62.0 yearsNot reportedUKB
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