| Predicted Trait | |
| Reported Trait | Intracerebral hemorrhage |
| Mapped Trait(s) | intracerebral hemorrhage (EFO_0005669) |
| Score Construction | |
| PGS Name | GRS_ICH |
| Development Method | |
| Name | LDpred2-grid |
| Parameters | h2=0.7288, p=0.1, sparse=FALSE |
| Variants | |
| Original Genome Build | NR |
| Number of Variants | 682,890 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000450 |
| Citation (link to publication) | Mayerhofer E et al. Stroke (2023) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 3,026 individuals (100%) |
| Score Development/Training | European: 100% 862 individuals (100%) |
| PGS Evaluation | |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST002389 Europe PMC: 24656865 |
3,026 individuals | European | NR |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | [ ,
59.0 % Male samples |
European | UKB | Cases with history of ICH at baseline and the same number of randomly selected age- and sex-matched ICH-free controls. | Mean = 60.0 years | Mean = 11.9 years | — | — |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM017258 | PSS010179| Multi-ancestry (including European)| 5,530 individuals |
PGP000450 | Mayerhofer E et al. Stroke (2023) |
Reported Trait: Incident intracerebral hemorrhage in anticoagulation therapy | HR: 1.24 [1.01, 1.53] | — | R²: 0.02 | age at baseline (controls) or ICH event (cases), sex, PC1 to 10, and genotyping array | — |
| PPM017259 | PSS010179| Multi-ancestry (including European)| 5,530 individuals |
PGP000450 | Mayerhofer E et al. Stroke (2023) |
Reported Trait: Incident intracerebral hemorrhage in anticoagulation therapy | HR: 1.33 [1.11, 1.59] | C-index: 0.57 [0.5, 0.64] | — | age at baseline (controls) or ICH event (cases), sex, PC1 to 10, and genotyping array, clinical risk score | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS010179 | The test cohort consisted of individuals without a history of ICH at baseline and anticoagulant use defined by self-report in the verbal interview at inclusion. Furthermore, individuals were included if they had a diagnosis of the International Classification of Diseases, Tenth Revision code Z92.1 (personal history of long-term (current) use of anticoagulants) or D68.3 (hemorrhagic disorder due to circulating anticoagulants) at baseline or a prescription of an anticoagulant medication between baseline and 6 months thereafter in the primary care data | Mean = 11.9 years | [ ,
69.0 % Male samples |
Mean = 62.0 years | European | — | UKB | — |
| PSS010179 | The test cohort consisted of individuals without a history of ICH at baseline and anticoagulant use defined by self-report in the verbal interview at inclusion. Furthermore, individuals were included if they had a diagnosis of the International Classification of Diseases, Tenth Revision code Z92.1 (personal history of long-term (current) use of anticoagulants) or D68.3 (hemorrhagic disorder due to circulating anticoagulants) at baseline or a prescription of an anticoagulant medication between baseline and 6 months thereafter in the primary care data | Mean = 11.9 years | [ ,
69.0 % Male samples |
Mean = 62.0 years | Not reported | — | UKB | — |