Polygenic Score (PGS) ID: PGS003466

Predicted Trait
Reported Trait Fasting insulin
Mapped Trait(s) fasting blood insulin measurement (EFO_0004466)
Released in PGS Catalog: March 24, 2023
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Score Details

Score Construction
PGS Name LDPred2_FI
Development Method
Name LDpred2
Parameters INFO score>0.8, MAF >=0.01
Variants
Original Genome Build GRCh38
Number of Variants 850,362
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000456
Citation (link to publication) Zhang Y et al. EBioMedicine (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • African
  • East Asian
  • European
  • Hispanic or Latin American
  • South Asian
213,645 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90002241
Europe PMC: 34059833
 213,645 individuals African American or Afro-Caribbean, East Asian, European, Hispanic or Latin American, South Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017276 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index β: -0.004 (0.01) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017299 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea β: -0.003 (0.024) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017344 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index in obsese β: 0.02 (0.017) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017345 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index in non-obsese β: -0.013 (0.012) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017364 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea in obsese β: 0.039 (0.034) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017365 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea in non-obsese β: -0.04 (0.035) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017394 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index x obesity interaction β: 0.025 (1.026) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017404 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea x obesity interaction β: 1.091 (0.049) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010185 — — 1,115 individuals,
41.1 % Male samples
 Mean = 46.18 years Hispanic or Latin American — HCHS, SOL —