Polygenic Score (PGS) ID: PGS003473

Predicted Trait
Reported Trait Insomnia
Mapped Trait(s) insomnia measurement (EFO_0007876)
Released in PGS Catalog: March 24, 2023
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Score Details

Score Construction
PGS Name LDPred2_Insomnia
Development Method
Name LDpred2
Parameters INFO score>0.8, MAF >=0.01
Variants
Original Genome Build GRCh38
Number of Variants 850,033
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000456
Citation (link to publication) Zhang Y et al. EBioMedicine (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
453,379 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007387
Europe PMC: 30804566
 453,379 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017283 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index β: 0.03 (0.01) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017306 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea β: 0.059 (0.024) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017350 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index in obsese β: 0.016 (0.017) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017351 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index in non-obsese β: 0.044 (0.012) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017370 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea in obsese β: 0.044 (0.034) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017371 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea in non-obsese β: 0.083 (0.034) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017397 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Respiratory event index x obesity interaction β: -0.035 (0.966) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017407 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Obstructive sleep apnea x obesity interaction β: 0.95 (0.05) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010185 — — 1,115 individuals,
41.1 % Male samples
 Mean = 46.18 years Hispanic or Latin American — HCHS, SOL —