Polygenic Score (PGS) ID: PGS003478

Predicted Trait
Reported Trait Red blood cell count
Mapped Trait(s) erythrocyte count (EFO_0004305)
Released in PGS Catalog: March 24, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name LDPred2_RBC
Development Method
Name LDpred2
Parameters INFO score>0.8, MAF >=0.01
Variants
Original Genome Build GRCh38
Number of Variants 860,281
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000456
Citation (link to publication) Zhang Y et al. EBioMedicine (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • African
  • European
  • East Asian
  • Hispanic or Latin American
  • South Asian
727,624 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST90002367
Europe PMC: 32888493
727,624 individualsAfrican American or Afro-Caribbean, African unspecified, European, East Asian, Hispanic or Latin American, South AsianNR
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM017288PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
PGP000456 |
Zhang Y et al. EBioMedicine (2022)
Reported Trait: Respiratory event indexβ: -0.001 (0.01)——Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI—
PPM017311PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
PGP000456 |
Zhang Y et al. EBioMedicine (2022)
Reported Trait: Obstructive sleep apneaβ: 0.008 (0.024)——Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS010185——1,115 individuals,
41.1 % Male samples
Mean = 46.18 yearsHispanic or Latin American—HCHS, SOL—
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