Polygenic Score (PGS) ID: PGS003479

Predicted Trait
Reported Trait Obstructive sleep apnea
Mapped Trait(s) obstructive sleep apnea (EFO_0003918)
Released in PGS Catalog: March 24, 2023
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name LDPred2_SleepApnea
Development Method
Name LDpred2
Parameters INFO score>0.8, MAF >=0.01
Variants
Original Genome Build GRCh38
Number of Variants 836,839
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000456
Citation (link to publication) Zhang Y et al. EBioMedicine (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
217,955 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST011922
Europe PMC: 33243845
 217,955 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017318 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: DBP β: 0.038 (0.093) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017319 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Eosinophils count β: 0.003 (0.002) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017320 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: FEV1/FVC ratio β: -0.035 (0.06) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017321 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Fasting insulin β: 0.156 (0.091) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017322 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HbA1c β: 0.291 (0.122) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017323 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Hematocrit β: 0.039 (0.031) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017324 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Hemoglobin β: 0.014 (0.011) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017325 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-B β: 1.851 (1.169) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017326 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-IR β: 0.051 (0.03) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017327 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Heart rate β: 0.038 (0.106) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017328 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Insomnia β: 0.015 (0.049) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017329 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: LDL β: -0.358 (0.336) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017330 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Lymphocyte count β: 0.002 (0.007) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017331 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Mean arterial pressure β: 0.011 (0.102) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017333 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: RBC β: 0.003 (0.003) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017334 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Sleep duration β: 0.0 (0.013) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017335 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Total cholesterol β: -0.324 (0.391) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017336 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Triglycerides β: 0.725 (0.93) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017337 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: WBC β: 0.006 (0.018) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017338 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Waist hip ratio β: 0.002 (0.001) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017339 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: FEV1/FVC ratio β: 0.002 (0.018) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017380 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: DBP in obsese β: -0.084 (0.148) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017381 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: DBP in non-obsese β: 0.116 (0.118) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017382 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Fasting insulin in obsese β: 0.201 (0.161) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017383 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Fasting insulin in non-obsese β: 0.175 (0.089) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017384 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HbA1c in obsese β: 0.052 (0.197) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017385 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HbA1c in non-obsese β: 0.488 (0.151) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017386 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-B in obsese β: 0.724 (2.105) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017387 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-B in non-obsese β: 1.664 (1.084) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017388 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-IR in obsese β: 0.076 (0.057) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017389 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: HOMA-IR in non-obsese β: 0.062 (0.029) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017390 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Waist hip ratio in obsese β: 0.002 (0.001) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017391 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Waist hip ratio in non-obsese β: 0.001 (0.001) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —
PPM017332 PSS010185|
Hispanic or Latin American Ancestry|
1,115 individuals
 PGP000456 |
Zhang Y et al. EBioMedicine (2022)
 Reported Trait: Pulse pressure β: -0.073 (0.104) — — Age, sex, center, 5 genetic PCs, Hispanic/Latino background, BMI —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010185 — — 1,115 individuals,
41.1 % Male samples
 Mean = 46.18 years Hispanic or Latin American — HCHS, SOL —