Predicted Trait | |
Reported Trait | Aspartate aminotransferase level |
Mapped Trait(s) | aspartate aminotransferase measurement (EFO_0004736) |
Score Construction | |
PGS Name | cont-decay-log_AST |
Development Method | |
Name | LDpred2-auto |
Parameters | vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 979,739 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000457 |
Citation (link to publication) | Ding Y et al. bioRxiv (2022) Preprint |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 352,236 individuals, 0.46 % Male samples |
European | UKB | — | Mean = 56.8 years Sd = 8.0 years |
— | white British | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM017451 | PSS010886| European Ancestry| 19,052 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Aspartate aminotransferase | — | — | partial-R2: 0.07 | sex, age, deprivation index, PC1-16 | — |
PPM017535 | PSS010802| European Ancestry| 3,922 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Aspartate aminotransferase | — | — | partial-R2: 0.05 | sex, age, deprivation index, PC1-16 | — |
PPM017703 | PSS010550| Greater Middle Eastern Ancestry| 1,095 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Aspartate aminotransferase | — | — | partial-R2: 0.06 | sex, age, deprivation index, PC1-16 | — |
PPM017871 | PSS010466| South Asian Ancestry| 5,926 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Aspartate aminotransferase | — | — | partial-R2: 0.05 | sex, age, deprivation index, PC1-16 | — |
PPM017955 | PSS010382| East Asian Ancestry| 1,692 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Aspartate aminotransferase | — | — | partial-R2: 0.03 | sex, age, deprivation index, PC1-16 | — |
PPM018039 | PSS010298| African Ancestry| 2,318 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Aspartate aminotransferase | — | — | partial-R2: 0.01 | sex, age, deprivation index, PC1-16 | — |
PPM017619 | PSS010634| European Ancestry| 6,155 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Aspartate aminotransferase | — | — | partial-R2: 0.07 | sex, age, deprivation index, PC1-16 | — |
PPM017787 | PSS010214| European Ancestry| 2,233 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Aspartate aminotransferase | — | — | partial-R2: 0.09 | sex, age, deprivation index, PC1-16 | — |
PPM018123 | PSS010718| African Ancestry| 3,611 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Aspartate aminotransferase | — | — | partial-R2: 0.0 | sex, age, deprivation index, PC1-16 | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS010718 | — | — | 3,611 individuals, 46.0 % Male samples |
Mean = 51.9 years Sd = 8.1 years |
African unspecified | Nigerian | UKB | — |
PSS010466 | — | — | 5,926 individuals, 54.0 % Male samples |
Mean = 53.3 years Sd = 8.4 years |
South Asian | Indian | UKB | — |
PSS010886 | — | — | 19,052 individuals, 46.0 % Male samples |
Mean = 56.9 years Sd = 7.9 years |
European | white British | UKB | — |
PSS010214 | — | — | 2,233 individuals, 45.0 % Male samples |
Mean = 58.1 years Sd = 7.1 years |
European | Ashkenazi | UKB | — |
PSS010634 | — | — | 6,155 individuals, 45.0 % Male samples |
Mean = 54.5 years Sd = 8.4 years |
European | Italian | UKB | — |
PSS010382 | — | — | 1,692 individuals, 34.0 % Male samples |
Mean = 52.4 years Sd = 7.8 years |
East Asian | Chinese | UKB | — |
PSS010802 | — | — | 3,922 individuals, 38.0 % Male samples |
Mean = 54.4 years Sd = 7.5 years |
European | Polish | UKB | — |
PSS010550 | — | — | 1,095 individuals, 60.0 % Male samples |
Mean = 51.9 years Sd = 7.9 years |
Greater Middle Eastern (Middle Eastern, North African or Persian) | Iranian | UKB | — |
PSS010298 | — | — | 2,318 individuals, 37.0 % Male samples |
Mean = 52.5 years Sd = 8.1 years |
African American or Afro-Caribbean | Caribbean | UKB | — |