Polygenic Score (PGS) ID: PGS003529

Predicted Trait
Reported Trait QRS duration
Mapped Trait(s) QRS duration (EFO_0005055)
Released in PGS Catalog: April 12, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name cont-decay-log_ECG_QRS_duration
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
28,486 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
28,486 individuals,
0.49 % Male samples
European UKB Mean = 55.2 years
Sd = 7.4 years
white British

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017457 PSS010893|
European Ancestry|
1,567 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: QRS duration partial-R2: 0.03 sex, age, deprivation index, PC1-16
PPM017541 PSS010809|
European Ancestry|
299 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: QRS duration partial-R2: 0.03 sex, age, deprivation index, PC1-16
PPM017625 PSS010641|
European Ancestry|
400 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: QRS duration partial-R2: 0.03 sex, age, deprivation index, PC1-16
PPM017709 PSS010557|
Greater Middle Eastern Ancestry|
42 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: QRS duration partial-R2: 0.04 sex, age, deprivation index, PC1-16
PPM017793 PSS010221|
European Ancestry|
186 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: QRS duration partial-R2: 0.02 sex, age, deprivation index, PC1-16
PPM017961 PSS010389|
East Asian Ancestry|
115 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: QRS duration partial-R2: 0.01 sex, age, deprivation index, PC1-16
PPM018129 PSS010725|
African Ancestry|
116 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: QRS duration partial-R2: 0.02 sex, age, deprivation index, PC1-16
PPM017877 PSS010473|
South Asian Ancestry|
253 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: QRS duration partial-R2: 0.04 sex, age, deprivation index, PC1-16
PPM018045 PSS010305|
African Ancestry|
67 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: QRS duration partial-R2: 0.0 sex, age, deprivation index, PC1-16

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010305 67 individuals,
30.0 % Male samples
Mean = 49.8 years
Sd = 6.5 years
African American or Afro-Caribbean Caribbean UKB
PSS010725 116 individuals,
55.0 % Male samples
Mean = 49.4 years
Sd = 6.7 years
African unspecified Nigerian UKB
PSS010473 253 individuals,
66.0 % Male samples
Mean = 51.4 years
Sd = 7.9 years
South Asian Indian UKB
PSS010221 186 individuals,
55.0 % Male samples
Mean = 56.5 years
Sd = 6.4 years
European Ashkenazi UKB
PSS010893 1,567 individuals,
50.0 % Male samples
Mean = 55.5 years
Sd = 7.4 years
European white British UKB
PSS010641 400 individuals,
47.0 % Male samples
Mean = 53.6 years
Sd = 7.5 years
European Italian UKB
PSS010389 115 individuals,
35.0 % Male samples
Mean = 51.1 years
Sd = 6.9 years
East Asian Chinese UKB
PSS010809 299 individuals,
38.0 % Male samples
Mean = 52.9 years
Sd = 6.6 years
European Polish UKB
PSS010557 42 individuals,
62.0 % Male samples
Mean = 53.8 years
Sd = 6.7 years
Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB