Polygenic Score (PGS) ID: PGS003530

Predicted Trait
Reported Trait Eosinophil percentage
Mapped Trait(s) eosinophil percentage of leukocytes (EFO_0007991)
Released in PGS Catalog: April 12, 2023
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Terms and Licenses
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Score Details

Score Construction
PGS Name cont-decay-log_eosinophil_perc
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
211,456 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 211,456 individuals,
0.5 % Male samples
 European UKB — Mean = 56.9 years
Sd = 7.9 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017458 PSS010894|
European Ancestry|
11,449 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Eosinophil percentage — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM017542 PSS010810|
European Ancestry|
2,277 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Eosinophil percentage — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM017710 PSS010558|
Greater Middle Eastern Ancestry|
659 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Eosinophil percentage — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017794 PSS010222|
European Ancestry|
1,249 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Eosinophil percentage — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017878 PSS010474|
South Asian Ancestry|
4,192 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Eosinophil percentage — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM018046 PSS010306|
African Ancestry|
1,285 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Eosinophil percentage — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018130 PSS010726|
African Ancestry|
2,085 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Eosinophil percentage — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017626 PSS010642|
European Ancestry|
3,283 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Eosinophil percentage — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017962 PSS010390|
East Asian Ancestry|
973 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Eosinophil percentage — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010558 — — 659 individuals,
65.0 % Male samples
 Mean = 52.0 years
Sd = 7.9 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010306 — — 1,285 individuals,
40.0 % Male samples
 Mean = 52.3 years
Sd = 7.9 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010726 — — 2,085 individuals,
50.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010474 — — 4,192 individuals,
58.0 % Male samples
 Mean = 53.4 years
Sd = 8.5 years		 South Asian Indian UKB —
PSS010894 — — 11,449 individuals,
50.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010222 — — 1,249 individuals,
48.0 % Male samples
 Mean = 58.2 years
Sd = 6.9 years		 European Ashkenazi UKB —
PSS010642 — — 3,283 individuals,
51.0 % Male samples
 Mean = 54.8 years
Sd = 8.4 years		 European Italian UKB —
PSS010390 — — 973 individuals,
38.0 % Male samples
 Mean = 52.5 years
Sd = 7.7 years		 East Asian Chinese UKB —
PSS010810 — — 2,277 individuals,
42.0 % Male samples
 Mean = 54.5 years
Sd = 7.4 years		 European Polish UKB —