Polygenic Score (PGS) ID: PGS003586

Predicted Trait
Reported Trait Pre-eclampsia
Mapped Trait(s) preeclampsia (EFO_0000668)
Released in PGS Catalog: June 22, 2023
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Score Details

Score Construction
PGS Name PE
Development Method
Name PRS-CS
Parameters phi=(1, 1x10^-2, 1x10^-4, and 1x10^-6 )
Variants
Original Genome Build hg37
Number of Variants 1,087,033
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000462
Citation (link to publication) Honigberg MC et al. Nat Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 78%
Additional Asian Ancestries: 21.2%
Hispanic or Latin American: 0.5%
African: 0.3%
468,391 individuals (100%)
Score Development/Training
European: 100%
212,034 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90271316
Europe PMC: 37248299
[
  • 3,223 cases
  • , 96,119 controls
]
 Asian unspecified 8 cohorts
  • BBJ
  • ,BioMe
  • ,EB
  • ,FinnGen
  • ,G&H
  • ,InterPregGen
  • ,MGBB
  • ,MGI
GWAS Catalog: GCST90271316
Europe PMC: 37248299
[
  • 20 cases
  • , 1,406 controls
]
 African unspecified 8 cohorts
  • BBJ
  • ,BioMe
  • ,EB
  • ,FinnGen
  • ,G&H
  • ,InterPregGen
  • ,MGBB
  • ,MGI
GWAS Catalog: GCST90271316
Europe PMC: 37248299
[
  • 14 cases
  • , 2,457 controls
]
 Hispanic or Latin American 8 cohorts
  • BBJ
  • ,BioMe
  • ,EB
  • ,FinnGen
  • ,G&H
  • ,InterPregGen
  • ,MGBB
  • ,MGI
GWAS Catalog: GCST90271316
Europe PMC: 37248299
[
  • 1,389 cases
  • , 351,259 controls
]
 European 8 cohorts
  • BBJ
  • ,BioMe
  • ,EB
  • ,FinnGen
  • ,G&H
  • ,InterPregGen
  • ,MGBB
  • ,MGI
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 212,034 individuals European UKB 423 women with a history of 255 preeclampsia/eclampsia, 482 women with a history of gestational hypertension only, and 256 211,129 parous women without a reported history of HDPs — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018280 PSS010956|
European Ancestry|
25,582 individuals
 PGP000462 |
Honigberg MC et al. Nat Med (2023)
 Reported Trait: Pre-eclampsia/eclampsia OR: 1.31 [1.24, 1.38] — — maternal age at delivery, age2, and the first ten principal components of genetic ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010956 — —
[
  • 1,569 cases
  • , 24,013 controls
]
 — European — HUNT —