Polygenic Score (PGS) ID: PGS003586

Predicted Trait
Reported Trait Pre-eclampsia
Mapped Trait(s) preeclampsia (EFO_0000668)
Released in PGS Catalog: June 22, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PE
Development Method
Name PRS-CS
Parameters phi=(1, 1x10^-2, 1x10^-4, and 1x10^-6 )
Variants
Original Genome Build hg37
Number of Variants 1,087,033
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000462
Citation (link to publication) Honigberg MC et al. Nat Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 78%
Additional Asian Ancestries: 21.2%
Hispanic or Latin American: 0.5%
African: 0.3%
468,391 individuals (100%)
Score Development/Training
European: 100%
212,034 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST90271316
Europe PMC: 37248299
[
  • 3,223 cases
  • , 96,119 controls
]
Asian unspecified8 cohorts
  • BBJ
  • ,BioMe
  • ,EB
  • ,FinnGen
  • ,G&H
  • ,InterPregGen
  • ,MGBB
  • ,MGI
GWAS Catalog: GCST90271316
Europe PMC: 37248299
[
  • 20 cases
  • , 1,406 controls
]
African unspecified8 cohorts
  • BBJ
  • ,BioMe
  • ,EB
  • ,FinnGen
  • ,G&H
  • ,InterPregGen
  • ,MGBB
  • ,MGI
GWAS Catalog: GCST90271316
Europe PMC: 37248299
[
  • 14 cases
  • , 2,457 controls
]
Hispanic or Latin American8 cohorts
  • BBJ
  • ,BioMe
  • ,EB
  • ,FinnGen
  • ,G&H
  • ,InterPregGen
  • ,MGBB
  • ,MGI
GWAS Catalog: GCST90271316
Europe PMC: 37248299
[
  • 1,389 cases
  • , 351,259 controls
]
European8 cohorts
  • BBJ
  • ,BioMe
  • ,EB
  • ,FinnGen
  • ,G&H
  • ,InterPregGen
  • ,MGBB
  • ,MGI
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Score Development/Training
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
—212,034 individualsEuropeanUKB423 women with a history of 255 preeclampsia/eclampsia, 482 women with a history of gestational hype... rtension only, and 256 211,129 parous women without a reported history of HDPsShow more————
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM018280PSS010956|
European Ancestry|
25,582 individuals
PGP000462 |
Honigberg MC et al. Nat Med (2023)
Reported Trait: Pre-eclampsia/eclampsiaOR: 1.31 [1.24, 1.38]——maternal age at delivery, age2, and the first ten principal components of genetic ancestry—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS010956——
[
  • 1,569 cases
  • , 24,013 controls
]
—European—HUNT—
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