Polygenic Score (PGS) ID: PGS003676

Predicted Trait
Reported Trait Right fimbria volume
Mapped Trait(s) hippocampus fimbria volume (EFO_0009402)
Released in PGS Catalog: April 28, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name R_fimbria_trans_ancestry_meta_analysis
Development Method
Name PRSice
Parameters The PGS was calculated using PRSice v.2.3.5 software with LD-pruning on the base datasets (clump-kb = 250kb, clump-r2 = 0.1). PRSice performed optimization of the P-value threshold for the most accurate prediction, as measured by r-squared (R2)
Variants
Original Genome Build GRCh37
Number of Variants 39,045
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000464
Citation (link to publication) Liu N et al. Nat Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 86.5%
East Asian: 13.5%
36,978 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Europe PMC: 37337106
31,968 individualsEuropeanUKB
Europe PMC: 37337106
5,010 individualsEast AsianCHIMGEN
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM018324PSS010958|
East Asian Ancestry|
1,999 individuals
PGP000464 |
Liu N et al. Nat Genet (2023)
Reported Trait: Right fimbria volume: 0.00509sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS0109581,999 individualsEast AsianCHIMGEN
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