Polygenic Score (PGS) ID: PGS003739

Predicted Trait
Reported Trait Colorectal cancer
Mapped Trait(s) colorectal carcinoma (EFO_1001951)
Released in PGS Catalog: June 1, 2023
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Score Details

Score Construction
PGS Name PRS81_CoC
Development Method
Name Genome-wide significant SNPs
Parameters imputation info score ≥0.3, MAF ≥ 0.01
Variants
Original Genome Build GRCh37
Number of Variants 81
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000470
Citation (link to publication) Xin J et al. EBioMedicine (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
32,072 individuals (100%)
Score Development/Training
European: 100%
2,621 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST012879
Europe PMC: 30510241
 32,072 individuals European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 2,621 individuals European UKB — Mean = 65.25 years — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018495 PSS010988|
European Ancestry|
470 individuals
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Reported Trait: Colorectal cancer OR: 1.37 [1.24, 1.51] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010988 — — 470 individuals Mean = 67.3 years European — TCGA —