Polygenic Score (PGS) ID: PGS003744

Predicted Trait
Reported Trait Renal cancer
Mapped Trait(s) renal carcinoma (EFO_0002890)
Released in PGS Catalog: June 1, 2023
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Score Details

Score Construction
PGS Name PRS14_RC
Development Method
Name Genome-wide significant SNPs
Parameters imputation info score ≥0.3, MAF ≥ 0.01
Variants
Original Genome Build GRCh37
Number of Variants 14
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000470
Citation (link to publication) Xin J et al. EBioMedicine (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
31,190 individuals (100%)
Score Development/Training
European: 100%
649 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004710
Europe PMC: 28598434
 31,190 individuals European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 649 individuals European UKB — Mean = 65.21 years — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018500 PSS010994|
European Ancestry|
692 individuals
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Reported Trait: Renal cancer OR: 1.24 [1.14, 1.35] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010994 — — 692 individuals Mean = 60.99 years European — TCGA —