Polygenic Score (PGS) ID: PGS003858

Predicted Trait
Reported Trait Obstructive sleep apnea (BMI adjusted)
Mapped Trait(s) obstructive sleep apnea (EFO_0003918)
Released in PGS Catalog: Sept. 1, 2023
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Score Details

Score Construction
PGS Name GRS6_BMIadj
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 6
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000496
Citation (link to publication) Sofer T et al. EBioMedicine (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 72.2%
African: 18.7%
Hispanic or Latin American: 7.9%
Additional Asian Ancestries: 1.3%
568,576 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • African
  • Additional Asian Ancestries
  • European
  • Hispanic or Latin American
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 106,445 individuals,
86.3 % Male samples
 African unspecified MVP
— 7,149 individuals,
88.42 % Male samples
 Asian unspecified MVP
— 410,268 individuals,
92.74 % Male samples
 European MVP
— 44,714 individuals,
90.3 % Male samples
 Hispanic or Latin American MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018711 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI unadjusted obstructive sleep apnea β: 0.048 (0.015) AUROC: 0.62 [0.61, 0.64] — age, sex, genetic batch, PCs 1-10 —
PPM018712 PSS011076|
Multi-ancestry (including European)|
40,193 individuals
 PGP000496 |
Sofer T et al. EBioMedicine (2023)
 Reported Trait: BMI adjusted obstructive sleep apnea β: 0.066 (0.017) AUROC: 0.77 [0.76, 0.79] — BMI, age, sex, genetic batch, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011076 — — 2,023 individuals,
37.4 % Male samples
 Mean = 53.16 years
Sd = 16.23 years		 African unspecified — MGBB —
PSS011076 — — 932 individuals,
41.8 % Male samples
 Mean = 47.0 years
Sd = 15.67 years		 Asian unspecified — MGBB —
PSS011076 — — 34,764 individuals,
46.7 % Male samples
 Mean = 60.62 years
Sd = 16.83 years		 European — MGBB —
PSS011076 — — 1,182 individuals,
31.3 % Male samples
 Mean = 52.29 years
Sd = 16.56 years		 Hispanic or Latin American — MGBB —
PSS011076 — — 1,292 individuals,
46.8 % Male samples
 Mean = 52.08 years
Sd = 18.42 years		 Not reported — MGBB —