| Predicted Trait | |
| Reported Trait | Whole body water mass |
| Mapped Trait(s) | whole body water mass (EFO_0009805) |
| Additional Trait Information | http://ipgs.mit.edu/tanigawakellis2023/INI23102 |
| Score Construction | |
| PGS Name | INI23102 |
| Development Method | |
| Name | snpnet |
| Parameters | inclusive PGS |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 43,166 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000502 |
| Citation (link to publication) | Tanigawa Y et al. AJHG (2023) |
| Ancestry Distribution | |
| Score Development/Training | |
| PGS Evaluation | |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| — | 319,969 individuals | European, South Asian, African unspecified, Other admixed ancestry | UKB | — | — | — | European, South Asian, African unspecified, Other admixed ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM018829 | PSS011120| European Ancestry| 66,617 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Whole body water mass | — | — | R²: 0.76001 [0.75686, 0.76316] PGS R2 (no covariates): 0.0537 [0.0504, 0.057] Incremental R2 (full-covars): 0.0541 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018830 | PSS011105| European Ancestry| 2,837 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Whole body water mass | — | — | R²: 0.75815 [0.74282, 0.77347] PGS R2 (no covariates): 0.0659 [0.04845, 0.08335] Incremental R2 (full-covars): 0.05792 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018831 | PSS011118| South Asian Ancestry| 1,457 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Whole body water mass | — | — | R²: 0.69263 [0.66668, 0.71857] PGS R2 (no covariates): 0.02973 [0.01276, 0.04669] Incremental R2 (full-covars): 0.04434 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018832 | PSS011158| African Ancestry| 1,169 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Whole body water mass | — | — | R²: 0.58375 [0.54806, 0.61944] PGS R2 (no covariates): 0.00794 [-0.00198, 0.01785] Incremental R2 (full-covars): 0.00256 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018833 | PSS011176| Multi-ancestry (excluding European)| 7,842 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Whole body water mass | — | — | R²: 0.74875 [0.73923, 0.75827] PGS R2 (no covariates): 0.03942 [0.03107, 0.04777] Incremental R2 (full-covars): 0.0395 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011105 | — | — | 2,837 individuals | — | European (non-white British ancestry) | — | UKB | — |
| PSS011118 | — | — | 1,457 individuals | — | South Asian | — | UKB | — |
| PSS011120 | — | — | 66,617 individuals | — | European (white British ancestry) | — | UKB | — |
| PSS011158 | — | — | 1,169 individuals | — | African unspecified | — | UKB | — |
| PSS011176 | — | — | 7,842 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |