Predicted Trait | |
Reported Trait | Arm fat mass (R) |
Mapped Trait(s) | fat body mass (EFO_0005409) |
Additional Trait Information | http://ipgs.mit.edu/tanigawakellis2023/INI23120 |
Score Construction | |
PGS Name | INI23120 |
Development Method | |
Name | snpnet |
Parameters | inclusive PGS |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 29,790 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000502 |
Citation (link to publication) | Tanigawa Y et al. AJHG (2023) |
Ancestry Distribution | |
Score Development/Training | |
PGS Evaluation |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 319,885 individuals | European, South Asian, African unspecified, Other admixed ancestry | UKB | — | — | — | European, South Asian, African unspecified, Other admixed ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM018899 | PSS011134| European Ancestry| 66,604 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Arm fat mass (right) | — | — | R²: 0.14871 [0.14377, 0.15365] PGS R2 (no covariates): 0.08625 [0.08221, 0.09029] Incremental R2 (full-covars): 0.08473 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018901 | PSS011118| South Asian Ancestry| 1,457 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Arm fat mass (right) | — | — | R²: 0.19809 [0.1619, 0.23429] PGS R2 (no covariates): 0.07372 [0.04821, 0.09922] Incremental R2 (full-covars): 0.04848 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018902 | PSS011158| African Ancestry| 1,169 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Arm fat mass (right) | — | — | R²: 0.13404 [0.09846, 0.16962] PGS R2 (no covariates): 0.00846 [-0.00178, 0.01869] Incremental R2 (full-covars): -0.0561 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018903 | PSS011178| Multi-ancestry (excluding European)| 7,840 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Arm fat mass (right) | — | — | R²: 0.14567 [0.13139, 0.15994] PGS R2 (no covariates): 0.0796 [0.06823, 0.09097] Incremental R2 (full-covars): 0.06809 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018900 | PSS011105| European Ancestry| 2,837 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Arm fat mass (right) | — | — | R²: 0.12394 [0.1015, 0.14639] PGS R2 (no covariates): 0.08183 [0.06272, 0.10095] Incremental R2 (full-covars): 0.083 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011178 | — | — | 7,840 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |
PSS011118 | — | — | 1,457 individuals | — | South Asian | — | UKB | — |
PSS011158 | — | — | 1,169 individuals | — | African unspecified | — | UKB | — |
PSS011134 | — | — | 66,604 individuals | — | European (white British ancestry) |
— | UKB | — |
PSS011105 | — | — | 2,837 individuals | — | European (non-white British ancestry) |
— | UKB | — |