| Predicted Trait | |
| Reported Trait | Mean corpuscular volume |
| Mapped Trait(s) | erythrocyte volume (OBA_0003460) |
| Additional Trait Information | http://ipgs.mit.edu/tanigawakellis2023/INI30040 |
| Score Construction | |
| PGS Name | INI30040 |
| Development Method | |
| Name | snpnet |
| Parameters | inclusive PGS |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 21,818 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000502 |
| Citation (link to publication) | Tanigawa Y et al. AJHG (2023) |
| Ancestry Distribution | |
| Score Development/Training | |
| PGS Evaluation | |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| — | 316,084 individuals | European, South Asian, African unspecified, Other admixed ancestry | UKB | — | — | — | European, South Asian, African unspecified, Other admixed ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM018959 | PSS011136| European Ancestry| 65,932 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Mean corpuscular volume | — | — | R²: 0.21483 [0.20935, 0.22031] PGS R2 (no covariates): 0.1996 [0.19422, 0.20499] Incremental R2 (full-covars): 0.19669 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018960 | PSS011109| European Ancestry| 2,813 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Mean corpuscular volume | — | — | R²: 0.21868 [0.19209, 0.24527] PGS R2 (no covariates): 0.19629 [0.17038, 0.22221] Incremental R2 (full-covars): 0.19227 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018961 | PSS011113| South Asian Ancestry| 1,433 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Mean corpuscular volume | — | — | R²: 0.13118 [0.09927, 0.1631] PGS R2 (no covariates): 0.10078 [0.07183, 0.12973] Incremental R2 (full-covars): 0.09425 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018962 | PSS011155| African Ancestry| 1,157 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Mean corpuscular volume | — | — | R²: 0.07522 [0.04675, 0.10368] PGS R2 (no covariates): 0.05806 [0.03259, 0.08353] Incremental R2 (full-covars): 0.05248 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018963 | PSS011166| Multi-ancestry (excluding European)| 7,746 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Mean corpuscular volume | — | — | R²: 0.18827 [0.17284, 0.20369] PGS R2 (no covariates): 0.14096 [0.12683, 0.15508] Incremental R2 (full-covars): 0.11206 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011109 | — | — | 2,813 individuals | — | European (non-white British ancestry) | — | UKB | — |
| PSS011113 | — | — | 1,433 individuals | — | South Asian | — | UKB | — |
| PSS011136 | — | — | 65,932 individuals | — | European (white British ancestry) | — | UKB | — |
| PSS011155 | — | — | 1,157 individuals | — | African unspecified | — | UKB | — |
| PSS011166 | — | — | 7,746 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |