Predicted Trait | |
Reported Trait | Red blood cell (erythrocyte) distribution width |
Mapped Trait(s) | Red cell distribution width (EFO_0009188) |
Additional Trait Information | http://ipgs.mit.edu/tanigawakellis2023/INI30070 |
Score Construction | |
PGS Name | INI30070 |
Development Method | |
Name | snpnet |
Parameters | inclusive PGS |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 12,557 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000502 |
Citation (link to publication) | Tanigawa Y et al. AJHG (2023) |
Ancestry Distribution | |
Score Development/Training | |
PGS Evaluation |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 316,084 individuals | European, South Asian, African unspecified, Other admixed ancestry | UKB | — | — | — | European, South Asian, African unspecified, Other admixed ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM018974 | PSS011136| European Ancestry| 65,932 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | R²: 0.09215 [0.088, 0.0963] PGS R2 (no covariates): 0.07947 [0.07556, 0.08338] Incremental R2 (full-covars): 0.07934 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018975 | PSS011109| European Ancestry| 2,813 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | R²: 0.10616 [0.08496, 0.12736] PGS R2 (no covariates): 0.08744 [0.06781, 0.10708] Incremental R2 (full-covars): 0.08479 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018976 | PSS011113| South Asian Ancestry| 1,433 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | R²: 0.06648 [0.04207, 0.09088] PGS R2 (no covariates): 0.05249 [0.03048, 0.07451] Incremental R2 (full-covars): 0.05172 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018977 | PSS011155| African Ancestry| 1,157 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | R²: 0.0264 [0.00865, 0.04415] PGS R2 (no covariates): 0.01807 [0.00326, 0.03288] Incremental R2 (full-covars): 0.01826 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018978 | PSS011166| Multi-ancestry (excluding European)| 7,746 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | R²: 0.08776 [0.07593, 0.09959] PGS R2 (no covariates): 0.06743 [0.05683, 0.07804] Incremental R2 (full-covars): 0.06076 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011109 | — | — | 2,813 individuals | — | European (non-white British ancestry) |
— | UKB | — |
PSS011113 | — | — | 1,433 individuals | — | South Asian | — | UKB | — |
PSS011155 | — | — | 1,157 individuals | — | African unspecified | — | UKB | — |
PSS011166 | — | — | 7,746 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |
PSS011136 | — | — | 65,932 individuals | — | European (white British ancestry) |
— | UKB | — |