Polygenic Score (PGS) ID: PGS003931

Predicted Trait
Reported Trait Red blood cell (erythrocyte) distribution width
Mapped Trait(s) Red cell distribution width (EFO_0009188)
Additional Trait Information http://ipgs.mit.edu/tanigawakellis2023/INI30070
Released in PGS Catalog: Nov. 1, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name INI30070
Development Method
Name snpnet
Parameters inclusive PGS
Variants
Original Genome Build GRCh37
Number of Variants 12,557
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000502
Citation (link to publication) Tanigawa Y et al. AJHG (2023)
Ancestry Distribution
Score Development/Training
Multi-ancestry (including European): 100%
  • European
  • South Asian
  • African
  • Additional Diverse Ancestries
316,084 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
Multi-ancestry (excluding European): 20%
  • East Asian
  • Additional Diverse Ancestries
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
—316,084 individualsEuropean, South Asian, African unspecified, Other admixed ancestryUKB———European, South Asian, African unspecified, Other admixed ancestry—
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM018974PSS011136|
European Ancestry|
65,932 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Red blood cell (erythrocyte) distribution width——R²: 0.09215 [0.088, 0.0963]
PGS R2 (no covariates): 0.07947 [0.07556, 0.08338]
Incremental R2 (full-covars): 0.07934		age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)—
PPM018975PSS011109|
European Ancestry|
2,813 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Red blood cell (erythrocyte) distribution width——R²: 0.10616 [0.08496, 0.12736]
PGS R2 (no covariates): 0.08744 [0.06781, 0.10708]
Incremental R2 (full-covars): 0.08479		age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)—
PPM018976PSS011113|
South Asian Ancestry|
1,433 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Red blood cell (erythrocyte) distribution width——R²: 0.06648 [0.04207, 0.09088]
PGS R2 (no covariates): 0.05249 [0.03048, 0.07451]
Incremental R2 (full-covars): 0.05172		age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)—
PPM018977PSS011155|
African Ancestry|
1,157 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Red blood cell (erythrocyte) distribution width——R²: 0.0264 [0.00865, 0.04415]
PGS R2 (no covariates): 0.01807 [0.00326, 0.03288]
Incremental R2 (full-covars): 0.01826		age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)—
PPM018978PSS011166|
Multi-ancestry (excluding European)|
7,746 individuals
PGP000502 |
Tanigawa Y et al. AJHG (2023)
Reported Trait: Red blood cell (erythrocyte) distribution width——R²: 0.08776 [0.07593, 0.09959]
PGS R2 (no covariates): 0.06743 [0.05683, 0.07804]
Incremental R2 (full-covars): 0.06076		age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18)—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011109——2,813 individuals—European
(non-white British ancestry)		—UKB—
PSS011113——1,433 individuals—South Asian—UKB—
PSS011136——65,932 individuals—European
(white British ancestry)		—UKB—
PSS011155——1,157 individuals—African unspecified—UKB—
PSS011166——7,746 individuals—East Asian, Other admixed ancestryEast Asian, Other admixed ancestryUKB—
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