Predicted Trait | |
Reported Trait | Platelet crit |
Mapped Trait(s) | platelet crit (EFO_0007985) |
Additional Trait Information | http://ipgs.mit.edu/tanigawakellis2023/INI30090 |
Score Construction | |
PGS Name | INI30090 |
Development Method | |
Name | snpnet |
Parameters | inclusive PGS |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 27,034 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000502 |
Citation (link to publication) | Tanigawa Y et al. AJHG (2023) |
Ancestry Distribution | |
Score Development/Training | |
PGS Evaluation |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 315,950 individuals | European, South Asian, African unspecified, Other admixed ancestry | UKB | — | — | — | European, South Asian, African unspecified, Other admixed ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM018984 | PSS011138| European Ancestry| 65,896 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Platelet crit | — | — | R²: 0.25161 [0.24596, 0.25727] PGS R2 (no covariates): 0.16315 [0.15806, 0.16824] Incremental R2 (full-covars): 0.16228 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018985 | PSS011109| European Ancestry| 2,813 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Platelet crit | — | — | R²: 0.24843 [0.22117, 0.27569] PGS R2 (no covariates): 0.17673 [0.15154, 0.20191] Incremental R2 (full-covars): 0.17323 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018986 | PSS011113| South Asian Ancestry| 1,433 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Platelet crit | — | — | R²: 0.24781 [0.20983, 0.28578] PGS R2 (no covariates): 0.11999 [0.08908, 0.1509] Incremental R2 (full-covars): 0.10886 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018987 | PSS011155| African Ancestry| 1,157 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Platelet crit | — | — | R²: 0.1523 [0.11518, 0.18943] PGS R2 (no covariates): 0.04384 [0.02137, 0.06631] Incremental R2 (full-covars): 0.02917 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018988 | PSS011167| Multi-ancestry (excluding European)| 7,743 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Platelet crit | — | — | R²: 0.22916 [0.213, 0.24532] PGS R2 (no covariates): 0.13828 [0.12425, 0.15231] Incremental R2 (full-covars): 0.13431 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011109 | — | — | 2,813 individuals | — | European (non-white British ancestry) |
— | UKB | — |
PSS011113 | — | — | 1,433 individuals | — | South Asian | — | UKB | — |
PSS011155 | — | — | 1,157 individuals | — | African unspecified | — | UKB | — |
PSS011167 | — | — | 7,743 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |
PSS011138 | — | — | 65,896 individuals | — | European (white British ancestry) |
— | UKB | — |