Predicted Trait | |
Reported Trait | Mean platelet (thrombocyte) volume |
Mapped Trait(s) | mean platelet volume (EFO_0004584) |
Additional Trait Information | http://ipgs.mit.edu/tanigawakellis2023/INI30100 |
Score Construction | |
PGS Name | INI30100 |
Development Method | |
Name | snpnet |
Parameters | inclusive PGS |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 31,032 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000502 |
Citation (link to publication) | Tanigawa Y et al. AJHG (2023) |
Ancestry Distribution | |
Score Development/Training | |
PGS Evaluation |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 316,082 individuals | European, South Asian, African unspecified, Other admixed ancestry | UKB | — | — | — | European, South Asian, African unspecified, Other admixed ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM018989 | PSS011144| European Ancestry| 65,930 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean platelet (thrombocyte) volume | — | — | R²: 0.36086 [0.35507, 0.36664] PGS R2 (no covariates): 0.35829 [0.35251, 0.36408] Incremental R2 (full-covars): 0.35783 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018990 | PSS011109| European Ancestry| 2,813 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean platelet (thrombocyte) volume | — | — | R²: 0.36427 [0.33635, 0.3922] PGS R2 (no covariates): 0.35942 [0.33147, 0.38737] Incremental R2 (full-covars): 0.35587 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018991 | PSS011113| South Asian Ancestry| 1,433 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean platelet (thrombocyte) volume | — | — | R²: 0.2322 [0.19468, 0.26972] PGS R2 (no covariates): 0.23172 [0.19421, 0.26922] Incremental R2 (full-covars): 0.22951 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018993 | PSS011166| Multi-ancestry (excluding European)| 7,746 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean platelet (thrombocyte) volume | — | — | R²: 0.30944 [0.29261, 0.32626] PGS R2 (no covariates): 0.31539 [0.29855, 0.33222] Incremental R2 (full-covars): 0.2903 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM018992 | PSS011155| African Ancestry| 1,157 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean platelet (thrombocyte) volume | — | — | R²: 0.10997 [0.07685, 0.1431] PGS R2 (no covariates): 0.10936 [0.0763, 0.14241] Incremental R2 (full-covars): 0.10916 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011109 | — | — | 2,813 individuals | — | European (non-white British ancestry) |
— | UKB | — |
PSS011144 | — | — | 65,930 individuals | — | European (white British ancestry) |
— | UKB | — |
PSS011113 | — | — | 1,433 individuals | — | South Asian | — | UKB | — |
PSS011155 | — | — | 1,157 individuals | — | African unspecified | — | UKB | — |
PSS011166 | — | — | 7,746 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |