| Predicted Trait | |
| Reported Trait | Platelet distribution width |
| Mapped Trait(s) | platelet component distribution width (EFO_0007984) |
| Additional Trait Information | http://ipgs.mit.edu/tanigawakellis2023/INI30110 |
| Score Construction | |
| PGS Name | INI30110 |
| Development Method | |
| Name | snpnet |
| Parameters | inclusive PGS |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 21,899 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000502 |
| Citation (link to publication) | Tanigawa Y et al. AJHG (2023) |
| Ancestry Distribution | |
| Score Development/Training | |
| PGS Evaluation | |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| — | 315,949 individuals | European, South Asian, African unspecified, Other admixed ancestry | UKB | — | — | — | European, South Asian, African unspecified, Other admixed ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM018994 | PSS011138| European Ancestry| 65,896 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Platelet distribution width | — | — | R²: 0.23112 [0.22556, 0.23669] PGS R2 (no covariates): 0.20884 [0.20339, 0.21428] Incremental R2 (full-covars): 0.20956 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018995 | PSS011109| European Ancestry| 2,813 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Platelet distribution width | — | — | R²: 0.20802 [0.18174, 0.23431] PGS R2 (no covariates): 0.19878 [0.17279, 0.22478] Incremental R2 (full-covars): 0.19816 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018996 | PSS011113| South Asian Ancestry| 1,433 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Platelet distribution width | — | — | R²: 0.18373 [0.14825, 0.21922] PGS R2 (no covariates): 0.16615 [0.13168, 0.20061] Incremental R2 (full-covars): 0.17042 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018997 | PSS011155| African Ancestry| 1,157 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Platelet distribution width | — | — | R²: 0.0902 [0.05954, 0.12087] PGS R2 (no covariates): 0.06578 [0.03889, 0.09267] Incremental R2 (full-covars): 0.05799 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018998 | PSS011167| Multi-ancestry (excluding European)| 7,743 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Platelet distribution width | — | — | R²: 0.22441 [0.20832, 0.2405] PGS R2 (no covariates): 0.19806 [0.18243, 0.21368] Incremental R2 (full-covars): 0.17896 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011109 | — | — | 2,813 individuals | — | European (non-white British ancestry) | — | UKB | — |
| PSS011113 | — | — | 1,433 individuals | — | South Asian | — | UKB | — |
| PSS011138 | — | — | 65,896 individuals | — | European (white British ancestry) | — | UKB | — |
| PSS011155 | — | — | 1,157 individuals | — | African unspecified | — | UKB | — |
| PSS011167 | — | — | 7,743 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |