Predicted Trait | |
Reported Trait | Basophil count |
Mapped Trait(s) | basophil count (EFO_0005090) |
Additional Trait Information | http://ipgs.mit.edu/tanigawakellis2023/INI30160 |
Score Construction | |
PGS Name | INI30160 |
Development Method | |
Name | snpnet |
Parameters | inclusive PGS |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 4,184 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000502 |
Citation (link to publication) | Tanigawa Y et al. AJHG (2023) |
Ancestry Distribution | |
Score Development/Training | |
PGS Evaluation |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 315,523 individuals | European, South Asian, African unspecified, Other admixed ancestry | UKB | — | — | — | European, South Asian, African unspecified, Other admixed ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM019019 | PSS011139| European Ancestry| 65,814 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Basophil count | — | — | R²: 0.01943 [0.01737, 0.02149] PGS R2 (no covariates): 0.01516 [0.01334, 0.01699] Incremental R2 (full-covars): 0.01498 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM019021 | PSS011112| South Asian Ancestry| 1,428 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Basophil count | — | — | R²: 0.00683 [-0.00149, 0.01515] PGS R2 (no covariates): 0.00551 [-0.00198, 0.013] Incremental R2 (full-covars): 0.00504 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM019020 | PSS011110| European Ancestry| 2,810 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Basophil count | — | — | R²: 0.02167 [0.01119, 0.03216] PGS R2 (no covariates): 0.01847 [0.00876, 0.02818] Incremental R2 (full-covars): 0.01766 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM019022 | PSS011154| African Ancestry| 1,154 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Basophil count | — | — | R²: 0.00981 [-0.00119, 0.02082] PGS R2 (no covariates): 0.00446 [-0.003, 0.01192] Incremental R2 (full-covars): 0.00447 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PPM019023 | PSS011168| Multi-ancestry (excluding European)| 7,732 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Basophil count | — | — | R²: 0.02131 [0.01506, 0.02757] PGS R2 (no covariates): 0.01354 [0.00851, 0.01856] Incremental R2 (full-covars): 0.01229 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011110 | — | — | 2,810 individuals | — | European (non-white British ancestry) |
— | UKB | — |
PSS011112 | — | — | 1,428 individuals | — | South Asian | — | UKB | — |
PSS011154 | — | — | 1,154 individuals | — | African unspecified | — | UKB | — |
PSS011168 | — | — | 7,732 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |
PSS011139 | — | — | 65,814 individuals | — | European (white British ancestry) |
— | UKB | — |