PGS Catalog - PGS003956 / Alzheimer's disease (Polygenic Score)

Polygenic Score (PGS) ID: PGS003956

Predicted Trait
Reported Trait	Alzheimer's disease
Mapped Trait(s)	Alzheimer disease (MONDO_0004975)

Released in PGS Catalog: Oct. 17, 2023

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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name	AD_Kunkle_AFR
Development Method
Name	PRSice-2
Parameters	NR
Variants
Original Genome Build	NR
Number of Variants	157
Effect Weight Type	beta

PGS Source
PGS Catalog Publication (PGP) ID	PGP000503
Citation (link to publication)	Sofer T et al. Alzheimers Res Ther (2023)

Ancestry Distribution
Source of Variant Associations (GWAS)	African: 100% 8,006 individuals (100%)
PGS Evaluation	Hispanic or Latin American: 100% 1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)

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Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
GWAS Catalog: GCST011696 Europe PMC: 33074286	8,006 individuals	African American or Afro-Caribbean	NR

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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM019087	PSS011180\| Hispanic or Latin American Ancestry\| 4,189 individuals	PGP000503 \| Sofer T et al. Alzheimers Res Ther (2023)	Reported Trait: Mild cognitive impairment	OR: 1.14 [1.02, 1.28]	—	—	age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study ce... nter, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele countsShow more	—
PPM019096	PSS011180\| Hispanic or Latin American Ancestry\| 4,189 individuals	PGP000503 \| Sofer T et al. Alzheimers Res Ther (2023)	Reported Trait: Cognititve function (SEVLT recall change)	β: -0.08 [-0.17, 0.0]	—	—	—	—

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Evaluated Samples

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PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS011180	—	—	4,189 individuals	Mean = 63.0 years	Hispanic or Latin American (Central American, South American, Mexican, Cuban, Dominican, Puerto-Rican)	—	SOL	SOL-INCA: Study of Latinos-Investigation of Neurocognitive Aging

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