Polygenic Score (PGS) ID: PGS003976

Predicted Trait
Reported Trait LDL cholesterol
Mapped Trait(s) low density lipoprotein cholesterol measurement (EFO_0004611)
Released in PGS Catalog: Nov. 1, 2023
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name EUR_without-UKB_LDL
Development Method
Name PRS-CSx
Parameters default
Variants
Original Genome Build GRCh37
Number of Variants 821,134
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000514
Citation (link to publication) Hassanin E et al. Front Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,320,016 individuals (100%)
PGS Evaluation
East Asian: 50%
European: 50%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
JSONXMLCSVTXTMS-Excel
Loading, please wait
Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST90239658
Europe PMC: 34887591
1,320,016 individualsEuropeanNR
Showing 1 to 1 of 1 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM019138PSS011207|
European Ancestry|
423,596 individuals
PGP000514 |
Hassanin E et al. Front Genet (2023)
Reported Trait: LDL level——R²: 10.6 %——
PPM019143PSS011201|
East Asian Ancestry|
68,978 individuals
PGP000514 |
Hassanin E et al. Front Genet (2023)
Reported Trait: LDL level——R²: 4.5 %——
Showing 1 to 2 of 2 rows

Evaluated Samples

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011201——68,978 individuals,
31.2 % Male samples
—East Asian—TWB—
PSS011207——423,596 individuals,
45.9 % Male samples
—European—UKB—
Showing 1 to 2 of 2 rows