Predicted Trait | |
Reported Trait | HbA1c |
Mapped Trait(s) | HbA1c measurement (EFO_0004541) |
Score Construction | |
PGS Name | megaprs.CV.GCST007954.HbA1c |
Development Method | |
Name | megaprs.CV |
Parameters | Model:Model168,Type:bayesr,Her_Scaling:1,Lasso_lambda:NA,Lasso_s:NA,Bolt_p:NA,Bolt_f2:NA,BayesR_p1:0.89,BayesR_p2:0.1,BayesR_p3:0.01,BayesR_p4:0 |
Variants | |
Original Genome Build | GRCh38 |
Number of Variants | 514,367 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000517 |
Citation (link to publication) | Monti R et al. Am J Hum Genet (2024) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST007954 Europe PMC: 28898252 |
88,355 individuals | European | NR |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 344,209 individuals | European | UKB | data field 30750 | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM019669 | PSS011242| South Asian Ancestry| 12,948 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Haemoglobin A1C | β: 0.02487 [0.00764872, 0.04208973] | — | R²: 0.00062 [0.0000585, 0.00177155] | 0 | beta = sd_trait/sd_pgs = pearson correlation |
PPM019670 | PSS011258| European Ancestry| 34,192 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Haemoglobin A1C | β: 0.16593 [0.15548016, 0.17638591] | — | R²: 0.02753 [0.02417408, 0.03111199] | 0 | beta = sd_trait/sd_pgs = pearson correlation |
PPM019671 | PSS011286| South Asian Ancestry| 8,748 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Haemoglobin A1C | β: 0.16274 [0.14205739, 0.18341402] | — | R²: 0.02648 [0.0201803, 0.0336407] | 0 | beta = sd_trait/sd_pgs = pearson correlation |
PPM019672 | PSS011272| European Ancestry| 86,050 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Haemoglobin A1C | β: 0.19138 [0.18502304, 0.19774227] | — | R²: 0.03886 [0.03631892, 0.04148397] | 0 | beta = sd_trait/sd_pgs = pearson correlation |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011258 | — | — | 34,192 individuals | — | European | — | HUNT | — |
PSS011272 | — | — | 86,050 individuals | — | European | — | UKB | — |
PSS011242 | — | — | 12,948 individuals | — | South Asian | — | G&H | — |
PSS011286 | — | — | 8,748 individuals | — | South Asian | — | UKB | — |