Predicted Trait | |
Reported Trait | Rheumatoid arthritis |
Mapped Trait(s) | rheumatoid arthritis (EFO_0000685) |
Additional Trait Information | seropositive RA |
Score Construction | |
PGS Name | prscs.auto.GCST90013534.RA |
Development Method | |
Name | PRS-CS-auto |
Parameters | phi:auto |
Variants | |
Original Genome Build | GRCh38 |
Number of Variants | 755,048 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000517 |
Citation (link to publication) | Monti R et al. Am J Hum Genet (2024) |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
---|---|---|---|
GWAS Catalog: GCST90013534 Europe PMC: 33310728 | 58,284 individuals | European | NR |
GWAS Catalog: GCST90013534 Europe PMC: 33310728 | 253,008 individuals | East Asian | NR |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
|
Additional Sample/Cohort Information
|
---|---|---|---|---|---|---|---|---|
— | 820 individuals | European | UKB | — | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM020045 | PSS011222| European Ancestry| 199,274 individuals | PGP000517 | Monti R et al. Am J Hum Genet (2024) | Reported Trait: Seropositive RA | OR: 1.43309 [1.37789918, 1.49048299] β: 0.35983 [0.32056001, 0.39910022] | AUROC: 0.60175 [0.58999494, 0.61350437] | R²: 0.01993 [0.01570594, 0.02462764] | 0 | beta = log(or)/sd_pgs |
PPM020046 | PSS011233| European Ancestry| 388,890 individuals | PGP000517 | Monti R et al. Am J Hum Genet (2024) | Reported Trait: Seropositive RA | OR: 1.64768 [1.61352054, 1.68256451] β: 0.49937 [0.47841846, 0.52031912] | AUROC: 0.63372 [0.62788781, 0.63955506] | R²: 0.03632 [0.03309896, 0.03953108] | 0 | beta = log(or)/sd_pgs |
PPM020047 | PSS011246| South Asian Ancestry| 44,057 individuals | PGP000517 | Monti R et al. Am J Hum Genet (2024) | Reported Trait: Seropositive RA | OR: 1.45841 [1.19873228, 1.77432944] β: 0.37734 [0.18126456, 0.57342257] | AUROC: 0.60742 [0.53398957, 0.68084175] | R²: 0.01948 [0.00432876, 0.05204534] | 0 | beta = log(or)/sd_pgs |
PPM020048 | PSS011262| European Ancestry| 66,865 individuals | PGP000517 | Monti R et al. Am J Hum Genet (2024) | Reported Trait: Seropositive RA | OR: 1.30074 [1.2314019, 1.37398385] β: 0.26293 [0.20815328, 0.31771444] | AUROC: 0.58564 [0.56934416, 0.60192786] | R²: 0.01181 [0.00719488, 0.01742899] | 0 | beta = log(or)/sd_pgs |
PPM020049 | PSS011275| European Ancestry| 90,274 individuals | PGP000517 | Monti R et al. Am J Hum Genet (2024) | Reported Trait: Seropositive RA | OR: 1.88898 [1.67167849, 2.13453009] β: 0.63604 [0.5138282, 0.75824653] | AUROC: 0.69466 [0.65809177, 0.73122596] | R²: 0.07313 [0.04487877, 0.10829372] | 0 | beta = log(or)/sd_pgs |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
---|---|---|---|---|---|---|---|---|
PSS011222 | — | — | [
| — | European | — | EB | — |
PSS011233 | RHEUMA_SEROPOS_OTH, ICD10: M05[8-9], ICD9: 7140A | — | [
| — | European | — | FinnGen | — |
PSS011246 | — | — | [
| — | South Asian | — | G&H | — |
PSS011262 | — | — | [
| — | European | — | HUNT | — |
PSS011275 | — | — | [
| — | European | — | UKB | — |