Polygenic Score (PGS) ID: PGS004114

Predicted Trait
Reported Trait Gout
Mapped Trait(s) gout (EFO_0004274)
Released in PGS Catalog: Dec. 19, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name pt_clump.auto.GCST008972.Gout
Development Method
Name pt_clump.auto
Parameters r2 = 0.1, window = 250kb, p = 1e-18
Variants
Original Genome Build GRCh38
Number of Variants 248
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000517
Citation (link to publication) Monti R et al. Am J Hum Genet (2024)
Ancestry Distribution
Score Development/Training
European: 100%
6,704 individuals (100%)
PGS Evaluation
European: 66.7%
South Asian: 33.3%
6 Sample Sets

Development Samples

Score Development/Training
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
—6,704 individualsEuropeanUKB—————
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM019820PSS011217|
European Ancestry|
199,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: GoutOR: 1.35293 [1.32659628, 1.37978264]
β: 0.30227 [0.28261648, 0.32192598]		AUROC: 0.58503 [0.57951662, 0.59054167]R²: 0.01612 [0.01400763, 0.01829906]0beta = log(or)/sd_pgs
PPM019821PSS011229|
European Ancestry|
257,781 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: GoutOR: 1.4164 [1.38595483, 1.44750518]
β: 0.34812 [0.32638931, 0.36984151]		AUROC: 0.59683 [0.59079682, 0.60285579]R²: 0.02079 [0.01822775, 0.02353939]0beta = log(or)/sd_pgs
PPM019823PSS011240|
South Asian Ancestry|
44,057 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: GoutOR: 1.6966 [1.50610858, 1.91117414]
β: 0.52862 [0.40952923, 0.64771779]		AUROC: 0.64275 [0.60834253, 0.67714816]R²: 0.04038 [0.02343705, 0.06487604]0beta = log(or)/sd_pgs
PPM019824PSS011256|
European Ancestry|
66,865 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: GoutOR: 1.52441 [1.44373045, 1.609599]
β: 0.42161 [0.36723035, 0.47598508]		AUROC: 0.61995 [0.60482036, 0.63508935]R²: 0.03182 [0.02447801, 0.04051747]0beta = log(or)/sd_pgs
PPM019826PSS011284|
South Asian Ancestry|
9,326 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: GoutOR: 1.39654 [1.2146057, 1.60571975]
β: 0.334 [0.19441949, 0.4735721]		AUROC: 0.59207 [0.55196044, 0.63218622]R²: 0.0164 [0.00610608, 0.03384948]0beta = log(or)/sd_pgs
PPM019828PSS011270|
European Ancestry|
90,274 individuals
PGP000517 |
Monti R et al. Am J Hum Genet (2024)
Reported Trait: GoutOR: 1.60047 [1.52497288, 1.67969876]
β: 0.4703 [0.42197662, 0.51861447]		AUROC: 0.63272 [0.61941303, 0.64603339]R²: 0.03943 [0.03181938, 0.04779961]0beta = log(or)/sd_pgs
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011217——
[
  • 10,646 cases
  • , 188,628 controls
]
—European—EB—
PSS011229M13_GOUT, ICD10: M10, ICD9: 2740—
[
  • 8,759 cases
  • , 249,022 controls
]
—European—FinnGen—
PSS011240——
[
  • 282 cases
  • , 43,775 controls
]
—South Asian—G&H—
PSS011256——
[
  • 1,318 cases
  • , 65,547 controls
]
—European—HUNT—
PSS011270——
[
  • 1,676 cases
  • , 88,598 controls
]
—European—UKB—
PSS011284——
[
  • 206 cases
  • , 9,120 controls
]
—South Asian—UKB—
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