Predicted Trait | |
Reported Trait | Prostate cancer |
Mapped Trait(s) | prostate carcinoma (EFO_0001663) |
Score Construction | |
PGS Name | sbayesr.auto.GCST006085.Prostate_cancer |
Development Method | |
Name | SBayesR-auto |
Parameters | auto with --robust |
Variants | |
Original Genome Build | GRCh38 |
Number of Variants | 945,385 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000517 |
Citation (link to publication) | Monti R et al. Am J Hum Genet (2024) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST006085 Europe PMC: 29892016 |
140,254 individuals | European | NR |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 9,671 individuals, 100.0 % Male samples |
European | UKB | — | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM019539 | PSS011221| European Ancestry| 68,516 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 1.83755 [1.76079665, 1.91764763] β: 0.60843 [0.56576635, 0.65109924] |
AUROC: 0.66652 [0.65523959, 0.67779057] | R²: 0.08398 [0.07344274, 0.09506364] | 0 | beta = log(or)/sd_pgs |
PPM019540 | PSS011232| European Ancestry| 171,474 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 2.10912 [2.07031069, 2.14865068] β: 0.74627 [0.72769869, 0.76484005] |
AUROC: 0.70032 [0.69582741, 0.70480679] | R²: 0.12127 [0.11622782, 0.12684792] | 0 | beta = log(or)/sd_pgs |
PPM019541 | PSS011245| South Asian Ancestry| 19,738 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 2.09532 [1.71819723, 2.55521892] β: 0.73971 [0.54127562, 0.9381379] |
AUROC: 0.70813 [0.65766064, 0.75860174] | R²: 0.08266 [0.04385125, 0.13403974] | 0 | beta = log(or)/sd_pgs |
PPM019542 | PSS011261| European Ancestry| 31,410 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 1.94637 [1.86071817, 2.03596439] β: 0.66597 [0.62096253, 0.71096961] |
AUROC: 0.68099 [0.66968894, 0.69228485] | R²: 0.09676 [0.08473465, 0.10933361] | 0 | beta = log(or)/sd_pgs |
PPM019543 | PSS011289| South Asian Ancestry| 4,976 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 2.33868 [1.93329423, 2.82907628] β: 0.84959 [0.65922541, 1.03995025] |
AUROC: 0.72874 [0.68089354, 0.77659441] | R²: 0.10918 [0.06519807, 0.16739921] | 0 | beta = log(or)/sd_pgs |
PPM019544 | PSS011274| European Ancestry| 41,305 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Prostate cancer | OR: 2.05644 [1.97084383, 2.14575861] β: 0.72098 [0.67846179, 0.76349315] |
AUROC: 0.6931 [0.68251948, 0.70367807] | R²: 0.1164 [0.10387553, 0.12958633] | 0 | beta = log(or)/sd_pgs |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011274 | — | — | [ ,
100.0 % Male samples |
— | European | — | UKB | — |
PSS011245 | — | — | [ ,
100.0 % Male samples |
— | South Asian | — | G&H | — |
PSS011221 | — | — | [ ,
100.0 % Male samples |
— | European | — | EB | — |
PSS011289 | — | — | [ ,
100.0 % Male samples |
— | South Asian | — | UKB | — |
PSS011261 | — | — | [ ,
100.0 % Male samples |
— | European | — | HUNT | — |
PSS011232 | C3_PROSTATE, ICD10: C61, ICD9: 185 | — | [ ,
100.0 % Male samples |
— | European | — | FinnGen | — |