Polygenic Score (PGS) ID: PGS004165

Predicted Trait
Reported Trait Lung cancer
Mapped Trait(s) lung carcinoma (EFO_0001071)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name PRS21_LC
Development Method
Name Genome-wide significant SNPs
Parameters r2 > 0.1, p<.00058
Variants
Original Genome Build NR
Number of Variants 21
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000518
Citation (link to publication) Wei X et al. Int J Cancer (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 65.1%
European: 34.9%
59,806 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90277434
Europe PMC: 37846649
 16,870 individuals East Asian NR
GWAS Catalog: GCST008836
Europe PMC: 31326317
 22,090 individuals East Asian NR
GWAS Catalog: GCST008836
Europe PMC: 31326317
 20,846 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020096 PSS011294|
East Asian Ancestry|
55,266 individuals
 PGP000518 |
Wei X et al. Int J Cancer (2023)
 Reported Trait: Lung cancer in never smokers HR: 1.29 [1.18, 1.41] — — age, education, BMI, COPD history, personal history of cancer, family history of cancer, and the first 10 principal components of ancestry —
PPM020097 PSS011294|
East Asian Ancestry|
55,266 individuals
 PGP000518 |
Wei X et al. Int J Cancer (2023)
 Reported Trait: Incident lung cancer in never smokers — — Hazard ratio (HR, high vs low risk): 2.09 [1.56, 2.8] age, first 10 principal components of ancestry, MI, education, COPD history, personal history of cancer and family history of cancer —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011294 — — 55,266 individuals,
0.0 % Male samples
 — East Asian — CKB —