| Predicted Trait | |
| Reported Trait | Diastolic blood pressure |
| Mapped Trait(s) | diastolic blood pressure (EFO_0006336) |
| Score Construction | |
| PGS Name | PRS732_DBP |
| Development Method | |
| Name | Genome-wide significant SNPs |
| Parameters | r2 <0.1, p<5e-08 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 732 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000529 |
| Citation (link to publication) | Acosta JN et al. Neurology (2023) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 757,601 individuals (100%) |
| PGS Evaluation | European: 100% 2 Sample Sets |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
GWAS Catalog: GCST006630 Europe PMC: 30224653 | 757,601 individuals | European | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM020231 | PSS011310| European Ancestry| 1,750 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Resistant blood pressure | — | — | Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.56 [0.92, 2.7] | — | — |
| PPM020235 | PSS011309| European Ancestry| 408,475 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Systolic blood pressure in all stroke | — | — | Beta (beta, top PRS quintile vs bottom PRS quintile): 3.52 (0.42) | age, sex, and vascular risk factors | — |
| PPM020236 | PSS011309| European Ancestry| 408,475 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Uncontrolled blood pressure in all stroke | — | — | Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.6 [1.35, 1.89] | age, sex, and vascular risk factors | — |
| PPM020237 | PSS011309| European Ancestry| 408,475 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Resistant blood pressure in all stroke | — | — | Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.24 [1.6, 3.19] | age, sex, and vascular risk factors | — |
| PPM020241 | PSS011309| European Ancestry| 408,475 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Systolic blood pressure in Ischemic stroke | — | — | Beta (beta, top PRS quintile vs bottom PRS quintile): 2.96 (0.84) | age, sex, and vascular risk factors | — |
| PPM020242 | PSS011309| European Ancestry| 408,475 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Uncontrolled blood pressure in Ischemic stroke | — | — | Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.45 [1.03, 2.03] | age, sex, and vascular risk factors | — |
| PPM020243 | PSS011309| European Ancestry| 408,475 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Resistant blood pressure in Ischemic stroke | — | — | Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 3.0 [1.62, 5.88] | age, sex, and vascular risk factors | — |
| PPM020247 | PSS011309| European Ancestry| 408,475 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Systolic blood pressure in Hemorrhagic stroke | — | — | Beta (beta, top PRS quintile vs bottom PRS quintile): 3.66 (1.08) | age, sex, and vascular risk factors | — |
| PPM020248 | PSS011309| European Ancestry| 408,475 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Uncontrolled blood pressure in Hemorrhagic stroke | — | — | Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.63 [1.71, 4.1] | age, sex, and vascular risk factors | — |
| PPM020249 | PSS011309| European Ancestry| 408,475 individuals | PGP000529 | Acosta JN et al. Neurology (2023) | Reported Trait: Resistant blood pressure in Hemorrhagic stroke | — | — | Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.24 [0.84, 6.73] | age, sex, and vascular risk factors | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011309 | — | — | 408,475 individuals, 59.0 % Male samples | Mean = 61.0 years Sd = 7.0 years | European | — | UKB | — |
| PSS011310 | — | — | 1,750 individuals, 65.0 % Male samples | Mean = 68.0 years Sd = 11.0 years | European | — | VISP | — |