Polygenic Score (PGS) ID: PGS004238

Predicted Trait
Reported Trait Cardiovascular disease
Mapped Trait(s) cardiovascular disease (EFO_0000319)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name wGRS35
Development Method
Name Clumping and Thresholding (C+T)
Parameters p<5e-4, D'<0.8
Variants
Original Genome Build NR
Number of Variants 35
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000535
Citation (link to publication) Cheng CF et al. J Gene Med (2021)
Ancestry Distribution
Score Development/Training
East Asian: 100%
1,535 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
Europe PMC: 33350037
[
  • 326 cases
  • , 1,209 controls
]
,
53.16 % Male samples
 East Asian
(Han Chinese)		 NR The cardiovascular disease patients (cases) were diagnosed by a licensed medical doctor based on events (e.g. angina, myocardial infarction, stroke) and/or interventions (e.g. coronary angioplasty/stenting, coronary artery bypass grafting, carotid endarterectomy). — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020271 PSS011317|
East Asian Ancestry|
385 individuals
 PGP000535 |
Cheng CF et al. J Gene Med (2021)
 Reported Trait: Cardiovascular disease in patients with type II diabetes Mellitus — AUROC: 0.666 [0.595, 0.737] — — —
PPM020272 PSS011317|
East Asian Ancestry|
385 individuals
 PGP000535 |
Cheng CF et al. J Gene Med (2021)
 Reported Trait: Cardiovascular disease in patients with type II diabetes Mellitus — AUROC: 0.78 [0.717, 0.843] — Age, gender, body mass index —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011317 The cardiovascular disease patients (cases) were diagnosed by a licensed medical doctor based on events (e.g. angina, myocardial infarction, stroke) and/or interventions (e.g. coronary angioplasty/stenting, coronary artery bypass grafting, carotid endarterectomy). —
[
  • 68 cases
  • , 317 controls
]
,
51.42 % Male samples
 — East Asian
(Han Chinese)		 — NR —