Polygenic Score (PGS) ID: PGS004601

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: Jan. 26, 2024
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Score Details

Score Construction
PGS Name PRS17_Pca
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 17
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000579
Citation (link to publication) Wu Y et al. Clin Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 57%
East Asian: 34%
Hispanic or Latin American: 5.6%
African: 3.4%
65,364 individuals (100%)
PGS Evaluation
East Asian: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST000750
Europe PMC: 20676098
 4,969 individuals East Asian NR
GWAS Catalog: GCST002944
Europe PMC: 26034056
 37,272 individuals European NR
GWAS Catalog: GCST002944
Europe PMC: 26034056
 2,251 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST002944
Europe PMC: 26034056
 3,226 individuals East Asian NR
GWAS Catalog: GCST002944
Europe PMC: 26034056
 3,629 individuals Hispanic or Latin American NR
GWAS Catalog: GCST001702
Europe PMC: 23023329
 2,425 individuals East Asian NR
GWAS Catalog: GCST003148
Europe PMC: 26443449
 7,394 individuals East Asian NR
Europe PMC: 23071574
[
  • 1,032 cases
  • , 571 controls
]
,
100.0 % Male samples
 East Asian
(Japanese)		 NR
Europe PMC: 22366784
[
  • 1,530 cases
  • , 1,065 controls
]
,
100.0 % Male samples
 East Asian
(Japanese)		 NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020757 PSS011394|
East Asian Ancestry|
2,628 individuals
 PGP000579 |
Wu Y et al. Clin Genet (2023)
 Reported Trait: Prostate cancer in males undergoing prostate biopsy — — p (PRS in cases vs controls): 5.56e-17 — —
PPM020758 PSS011393|
East Asian Ancestry|
2,425 individuals
 PGP000579 |
Wu Y et al. Clin Genet (2023)
 Reported Trait: Primary prostate cancer — — p (PRS in cases vs controls): 3.31e-23 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011393 — —
[
  • 1,417 cases
  • , 1,008 controls
]
,
100.0 % Male samples
 — East Asian
(Chinese)		 — NR —
PSS011394 — —
[
  • 1,137 cases
  • , 1,491 controls
]
,
100.0 % Male samples
 — East Asian
(Chinese)		 — NR —