Polygenic Score (PGS) ID: PGS004695

Predicted Trait
Reported Trait Idiopathic pulmonary fibrosis
Mapped Trait(s) idiopathic pulmonary fibrosis (EFO_0000768)
Released in PGS Catalog: March 18, 2024
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Score Details

Score Construction
PGS Name PRS23_IPF
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 23
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000598
Citation (link to publication) Wang X et al. Chemosphere (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
11,259 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST009758
Europe PMC: 31710517
 11,259 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020881 PSS011440|
European Ancestry|
402,042 individuals
 PGP000598 |
Wang X et al. Chemosphere (2023)
 Reported Trait: Incident idiopathic pulmonary fibrosis — — Hazard ratio (HR, high vs low PRS quintile): 3.78 [3.3, 4.34] Age, sex, education level, smoking status, pack-years of smoking, BMI —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011440 — Median = 11.78 years
[
  • 2,589 cases
  • , 399,453 controls
]
,
46.66 % Male samples
 Mean = 56.41 years
Sd = 8.04 years		 European — UKB —