| Predicted Trait | |
| Reported Trait | Alanine aminotransferase |
| Mapped Trait(s) | serum alanine aminotransferase measurement (EFO_0004735) |
| Score Construction | |
| PGS Name | ALT_PRSmix_eur |
| Development Method | |
| Name | PRSmix |
| Parameters | power=0.95; p=0.05 |
| Variants | |
| Original Genome Build | hg38 |
| Number of Variants | 559,731 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000604 |
| Citation (link to publication) | Truong B et al. Cell Genom (2024) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 20,988 individuals (100%) |
| PGS Evaluation | European: 100% 1 Sample Sets |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| — | 20,988 individuals | European | AllofUs | — | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM020940 | PSS011457| European Ancestry| 5,247 individuals | PGP000604 | Truong B et al. Cell Genom (2024) | Reported Trait: Alanine aminotransferase | — | — | Incremental R2 (Full model versus model with only covariates): 0.013 [0.007, 0.019] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011457 | — | — | 5,247 individuals | — | European | — | AllofUs | — |