Polygenic Score (PGS) ID: PGS004745

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: March 28, 2024
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name cad_PRSmixPlus_eur
Development Method
Name PRSmixPlus
Parameters power=0.95; p=1.83e-05
Variants
Original Genome Build hg38
Number of Variants 4,769,577
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000604
Citation (link to publication) Truong B et al. Cell Genom (2024)
Ancestry Distribution
Score Development/Training
European: 100%
29,863 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Score Development/Training
Loading, please wait
Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
29,863 individualsEuropeanAllofUsAt least one ICD or CPT code below: ICD9 410x, 411x, 412x; ICD10 I22x, I23x, I24.1, I25.2 CPT 92920-... 92979 (PCI), 33533-33536, 33517-33523, 33510-33516 (CABG) or self-reported personal history of MI or CAD.Show more
Showing 1 to 1 of 1 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

Loading, please wait
PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM020970PSS011487|
European Ancestry|
7,465 individuals
PGP000604 |
Truong B et al. Cell Genom (2024)
Reported Trait: Coronary artery diseaseIncremental R2 (Full model versus model with only covariates): 0.05 [0.04, 0.059]age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10Incremental R2 (Full model versus model with only covariates)
Showing 1 to 1 of 1 rows

Evaluated Samples

Loading, please wait
PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS0114877,465 individualsEuropeanAllofUs
Showing 1 to 1 of 1 rows