Predicted Trait | |
Reported Trait | Coronary artery disease |
Mapped Trait(s) | coronary artery disease (EFO_0001645) |
Score Construction | |
PGS Name | cad_PRSmixPlus_eur |
Development Method | |
Name | PRSmixPlus |
Parameters | power=0.95; p=1.83e-05 |
Variants | |
Original Genome Build | hg38 |
Number of Variants | 4,769,577 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000604 |
Citation (link to publication) | Truong B et al. Cell Genom (2024) |
Ancestry Distribution | |
Score Development/Training | European: 100% 29,863 individuals (100%) |
PGS Evaluation | European: 100% 1 Sample Sets |
Study Identifiers
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Sample Numbers
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Sample Ancestry
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Cohort(s)
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Phenotype Definitions & Methods
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Age of Study Participants
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Participant Follow-up Time
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Additional Ancestry Description
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Additional Sample/Cohort Information
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— | 29,863 individuals | European | AllofUs | At least one ICD or CPT code below: ICD9 410x, 411x, 412x; ICD10 I22x, I23x, I24.1, I25.2 CPT 92920-... 92979 (PCI), 33533-33536, 33517-33523, 33510-33516 (CABG) or self-reported personal history of MI or CAD.Show more | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
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PPM020970 | PSS011487| European Ancestry| 7,465 individuals | PGP000604 | Truong B et al. Cell Genom (2024) | Reported Trait: Coronary artery disease | — | — | Incremental R2 (Full model versus model with only covariates): 0.05 [0.04, 0.059] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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PSS011487 | — | — | 7,465 individuals | — | European | — | AllofUs | — |