Polygenic Score (PGS) ID: PGS004864

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: April 18, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS186_BMI
Development Method
Name Genome-wide significant SNPs
Parameters MAF > 0.01, HWE = p > 2.6e-4, genome wide significance = p < 5e-8, suggestive significance = p < 1e-6
Variants
Original Genome Build NR
Number of Variants 186
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000611
Citation (link to publication) de Toro-Martín J et al. JCI Insight (2018)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 76.8%
East Asian: 15.3%
African: 5.5%
Additional Asian Ancestries: 1%
South Asian: 0.6%
Hispanic or Latin American: 0.5%
Multi-ancestry (excluding European): 0.3%
  • South Asian
  • Additional Asian Ancestries
  • East Asian
877,203 individuals (100%)
PGS Evaluation
Not Reported: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002783
Europe PMC: 25673413
 236,781 individuals European 39 cohorts
  • AGES
  • ,ARIC
  • ,B58C
  • ,BRIGHT
  • ,CAPS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CROATIA-VIS
  • ,CoLaus
  • ,DGI
  • ,EGCUT
  • ,EPIC-Obesity
  • ,FHS
  • ,FTC
  • ,FUSION
  • ,Fenland
  • ,GENMETS
  • ,GerMIFS
  • ,HAPI
  • ,KORA S3
  • ,KORA S4
  • ,MICROS
  • ,MIGen
  • ,NESDA
  • ,NFBC
  • ,NHS
  • ,NTR
  • ,ORCADES
  • ,PLCO
  • ,RS
  • ,RUNMC
  • ,SASBAC
  • ,SEARCH
  • ,SHIP
  • ,UKBS
  • ,UKOPS
  • ,WTCCC
  • ,WTCCC CAD
  • ,deCODE
GWAS Catalog: GCST002783
Europe PMC: 25673413
 887 individuals African American or Afro-Caribbean 39 cohorts
  • AGES
  • ,ARIC
  • ,B58C
  • ,BRIGHT
  • ,CAPS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CROATIA-VIS
  • ,CoLaus
  • ,DGI
  • ,EGCUT
  • ,EPIC-Obesity
  • ,FHS
  • ,FTC
  • ,FUSION
  • ,Fenland
  • ,GENMETS
  • ,GerMIFS
  • ,HAPI
  • ,KORA S3
  • ,KORA S4
  • ,MICROS
  • ,MIGen
  • ,NESDA
  • ,NFBC
  • ,NHS
  • ,NTR
  • ,ORCADES
  • ,PLCO
  • ,RS
  • ,RUNMC
  • ,SASBAC
  • ,SEARCH
  • ,SHIP
  • ,UKBS
  • ,UKOPS
  • ,WTCCC
  • ,WTCCC CAD
  • ,deCODE
GWAS Catalog: GCST002783
Europe PMC: 25673413
 1,276 individuals Hispanic or Latin American 39 cohorts
  • AGES
  • ,ARIC
  • ,B58C
  • ,BRIGHT
  • ,CAPS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CROATIA-VIS
  • ,CoLaus
  • ,DGI
  • ,EGCUT
  • ,EPIC-Obesity
  • ,FHS
  • ,FTC
  • ,FUSION
  • ,Fenland
  • ,GENMETS
  • ,GerMIFS
  • ,HAPI
  • ,KORA S3
  • ,KORA S4
  • ,MICROS
  • ,MIGen
  • ,NESDA
  • ,NFBC
  • ,NHS
  • ,NTR
  • ,ORCADES
  • ,PLCO
  • ,RS
  • ,RUNMC
  • ,SASBAC
  • ,SEARCH
  • ,SHIP
  • ,UKBS
  • ,UKOPS
  • ,WTCCC
  • ,WTCCC CAD
  • ,deCODE
GWAS Catalog: GCST000298
Europe PMC: 19079261
 32,387 individuals European
(Italy)		 11 cohorts
  • B58C
  • ,CoLaus
  • ,DGI
  • ,EPIC
  • ,FUSION
  • ,KORA
  • ,NHS
  • ,PLCO
  • ,SardiNIA
  • ,UKBS
  • ,WTCCC
GWAS Catalog: GCST000830
Europe PMC: 20935630
 123,865 individuals European 44 cohorts
  • ADVANCE
  • ,AGES
  • ,ARIC
  • ,B58C
  • ,BRIGHT
  • ,CAPS
  • ,CHS
  • ,CoLaus
  • ,DGI
  • ,EGCUT
  • ,EPIC
  • ,ERF
  • ,FHS
  • ,FTC
  • ,FUSION
  • ,FamHS
  • ,Fenland
  • ,GENMETS
  • ,GerMIFS
  • ,HAPI
  • ,KORA F3
  • ,KORA F4
  • ,MICROS
  • ,MIGen
  • ,NESDA
  • ,NFBC
  • ,NHS
  • ,NSPHS
  • ,NTR
  • ,ORCADES
  • ,PLCO
  • ,PROCARDIS
  • ,RS
  • ,RUNMC
  • ,SASBAC
  • ,SEARCH
  • ,SHIP
  • ,SardiNIA
  • ,TwinsUK
  • ,UKBS
  • ,UKOPS
  • ,VIS
  • ,WTCCC
  • ,deCODE
GWAS Catalog: GCST002021
Europe PMC: 23669352
 13,627 individuals European 10 cohorts
  • B58C
  • ,EGCUT
  • ,ERF
  • ,FHS
  • ,GENEVA-DCS
  • ,HPFS
  • ,NHS
  • ,PLCO
  • ,SHIP
  • ,SardiNIA
GWAS Catalog: GCST001416
Europe PMC: 22344221
 26,620 individuals East Asian BBJ
GWAS Catalog: GCST000296
Europe PMC: 19079260
 72,598 individuals European 16 cohorts
  • ADDITION
  • ,B58C
  • ,CoLaus
  • ,DGI
  • ,EPIC
  • ,FUSION
  • ,Inter99
  • ,JH-SFHS
  • ,KORA
  • ,NBCS
  • ,NBS
  • ,NHS
  • ,PLCO
  • ,SardiNIA
  • ,UKBS
  • ,WTCCC
GWAS Catalog: GCST000296
Europe PMC: 19079260
 1,160 individuals African American or Afro-Caribbean 16 cohorts
  • ADDITION
  • ,B58C
  • ,CoLaus
  • ,DGI
  • ,EPIC
  • ,FUSION
  • ,Inter99
  • ,JH-SFHS
  • ,KORA
  • ,NBCS
  • ,NBS
  • ,NHS
  • ,PLCO
  • ,SardiNIA
  • ,UKBS
  • ,WTCCC
GWAS Catalog: GCST001676
Europe PMC: 22982992
 133,154 individuals European 35 cohorts
  • AGES
  • ,AMISH
  • ,ARIC
  • ,B58C
  • ,BSN
  • ,CAPS
  • ,CROATIA-KORCULA
  • ,CROATIA-SPLIT
  • ,CROATIA-VIS
  • ,CoLaus
  • ,DGI
  • ,EPIC
  • ,FUSION
  • ,FamHS
  • ,Fenland
  • ,FinGesture
  • ,HYPERGENES
  • ,LifeLines
  • ,MICROS
  • ,MIGen
  • ,NBS
  • ,NESDA
  • ,NFBC
  • ,NTR
  • ,ORCADES
  • ,PLCO
  • ,QIMR
  • ,RS
  • ,RUNMC
  • ,SASBAC
  • ,SEARCH
  • ,SORBS
  • ,WGHS
  • ,WTCCC
  • ,deCODE
GWAS Catalog: GCST002301
Europe PMC: 24348519
 2,860 individuals European CCHMC
GWAS Catalog: GCST000185
Europe PMC: 18454148
 16,876 individuals European B58C, CoLaus, EPIC, WTCCC, WTCCC CAD
GWAS Catalog: GCST000090
Europe PMC: 17903300
 1,341 individuals European FHS
GWAS Catalog: GCST002571
Europe PMC: 25133637
 5,354 individuals South Asian NR
GWAS Catalog: GCST000642
Europe PMC: 20397748
 11,536 individuals European ATR
GWAS Catalog: GCST000840
Europe PMC: 20966902
 1,780 individuals South East Asian CLHNS
GWAS Catalog: GCST000512
Europe PMC: 19851299
 3,925 individuals European CROATIA-VIS, ERF, MICROS, NSPHS, ORCADES
GWAS Catalog: GCST002435
Europe PMC: 24827717
 597 individuals East Asian NR
GWAS Catalog: GCST002461
Europe PMC: 24861553
 82,438 individuals East Asian 21 cohorts
  • CAGE
  • ,CLHNS
  • ,CRC
  • ,DFTJ
  • ,FAMHES
  • ,GenSalt
  • ,HEXA
  • ,Health2
  • ,KARE
  • ,KCPS
  • ,MESA
  • ,NHAPC
  • ,RIKEN
  • ,Rural
  • ,SDCS
  • ,SGWAS
  • ,SIH
  • ,SIMES
  • ,SP2
  • ,TGWAS
  • ,TUDR
GWAS Catalog: GCST002461
Europe PMC: 24861553
 4,301 individuals South East Asian 21 cohorts
  • CAGE
  • ,CLHNS
  • ,CRC
  • ,DFTJ
  • ,FAMHES
  • ,GenSalt
  • ,HEXA
  • ,Health2
  • ,KARE
  • ,KCPS
  • ,MESA
  • ,NHAPC
  • ,RIKEN
  • ,Rural
  • ,SDCS
  • ,SGWAS
  • ,SIH
  • ,SIMES
  • ,SP2
  • ,TGWAS
  • ,TUDR
GWAS Catalog: GCST001955
Europe PMC: 23563607
 16,068 individuals European 49 cohorts
  • ADVANCE
  • ,AGES
  • ,ARIC
  • ,B58C
  • ,BRIGHT
  • ,CAPS
  • ,CHS
  • ,COROGENE
  • ,CROATIA-VIS
  • ,CoLaus
  • ,DGI
  • ,EGCUT
  • ,EPIC
  • ,ERF
  • ,FHS
  • ,FUSION
  • ,FamHS
  • ,Fenland
  • ,GENMETS
  • ,GOOD
  • ,GerMIFS
  • ,HBCS
  • ,KORA S3
  • ,KORA S4
  • ,MGS
  • ,MICROS
  • ,MIGen
  • ,NESDA
  • ,NFBC
  • ,NHS
  • ,NSPHS
  • ,NTR
  • ,ORCADES
  • ,PLCO
  • ,PROCARDIS
  • ,RS
  • ,RUNMC
  • ,SASBAC
  • ,SEARCH
  • ,SHIP
  • ,SORBS
  • ,SardiNIA
  • ,TwinsUK
  • ,UKOPS
  • ,WGHS
  • ,WTCCC
  • ,WTCCC CAD
  • ,YFS
  • ,deCODE
GWAS Catalog: GCST002227
Europe PMC: 24064335
 8,463 individuals European 6 cohorts
  • COS
  • ,FHS
  • ,IFS
  • ,KCOS
  • ,OOS
  • ,WHI
GWAS Catalog: GCST002227
Europe PMC: 24064335
 7,478 individuals African American or Afro-Caribbean 6 cohorts
  • COS
  • ,FHS
  • ,IFS
  • ,KCOS
  • ,OOS
  • ,WHI
GWAS Catalog: GCST002227
Europe PMC: 24064335
 3,348 individuals Hispanic or Latin American 6 cohorts
  • COS
  • ,FHS
  • ,IFS
  • ,KCOS
  • ,OOS
  • ,WHI
GWAS Catalog: GCST002227
Europe PMC: 24064335
 1,624 individuals East Asian 6 cohorts
  • COS
  • ,FHS
  • ,IFS
  • ,KCOS
  • ,OOS
  • ,WHI
GWAS Catalog: GCST001967
Europe PMC: 23583978
 37,956 individuals African American or Afro-Caribbean 19 cohorts
  • AABC
  • ,AAPC
  • ,ARIC
  • ,BioVU
  • ,CARDIA
  • ,CFS
  • ,CHS
  • ,FamHS
  • ,GENOA
  • ,HANDLS
  • ,HEALTH ABC
  • ,HUFS
  • ,HYPERGENES
  • ,JHS
  • ,MESA
  • ,Maywood
  • ,Nigeria
  • ,WFSM
  • ,WHI-SHARe
GWAS Catalog: GCST001967
Europe PMC: 23583978
 1,188 individuals Sub-Saharan African 19 cohorts
  • AABC
  • ,AAPC
  • ,ARIC
  • ,BioVU
  • ,CARDIA
  • ,CFS
  • ,CHS
  • ,FamHS
  • ,GENOA
  • ,HANDLS
  • ,HEALTH ABC
  • ,HUFS
  • ,HYPERGENES
  • ,JHS
  • ,MESA
  • ,Maywood
  • ,Nigeria
  • ,WFSM
  • ,WHI-SHARe
GWAS Catalog: GCST001415
Europe PMC: 22344219
 22,762 individuals East Asian 8 cohorts
  • CAGE
  • ,CRC
  • ,KARE
  • ,SDCS
  • ,SGWAS
  • ,SIMES
  • ,SP2
  • ,TGWAS
GWAS Catalog: GCST001415
Europe PMC: 22344219
 2,522 individuals South East Asian 8 cohorts
  • CAGE
  • ,CRC
  • ,KARE
  • ,SDCS
  • ,SGWAS
  • ,SIMES
  • ,SP2
  • ,TGWAS
GWAS Catalog: GCST001415
Europe PMC: 22344219
 2,431 individuals South Asian, South East Asian, East Asian 8 cohorts
  • CAGE
  • ,CRC
  • ,KARE
  • ,SDCS
  • ,SGWAS
  • ,SIMES
  • ,SP2
  • ,TGWAS

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021100 PSS011528|
Ancestry Not Reported|
767 individuals
 PGP000611 |
de Toro-Martín J et al. JCI Insight (2018)
 Reported Trait: Low weight loss following bariatric surgery — AUROC: 0.888 NRI: 0.638 [0.466, 0.809]
IDI: 0.066 [0.041, 0.091]		 Age, sex, initial body mass index, and type of surgery —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011528 Of the 767 participants, 147 were assigned to the low weight loss (LWL) trajectory group following biliopancreatic diversion with duodenal switch whilst 620 were assigned to the high weight loss and normal weight loss (HWL+NWL) trajectory group following biliopancreatic diversion with duodenal switch. Of the 147 individuals within the LWL trajectory group, 34 underwent biliopancreatic diversion with duodenal switch via laparoscopy whilst 112 underwent the same procedure via open surgery. Of the 620 individuals within the HWL+NWL trajectory group, 396 underwent biliopancreatic diversion with duodenal switch via laparoscopy whilst 217 underwent the same procedure via open surgery. On the eve of the surgery, height and body weight were measured and used to calculate the initial BMI as the weight in kilograms divided by the square of the height in meters. Body weight was further measured during postoperative visits or phone calls thorough a follow-up period of 8 years. Percentage of excess body weight loss (EBWL) was then calculated at each follow-up time point (3, 6, 12, 24, 36, 48, 60, 72, 84, and 96 months) as the difference between actual body weight loss (calculated initial BMI minus actual BMI) and ideal body weight loss (calculated as the initial BMI minus ideal BMI fixed at 25 kg/m2). — 767 individuals,
28.16 % Male samples
 — Not reported — NR Participants were obtained from the Bariatric Surgery Clinic of the Quebec Heart and Lung Institute.