Polygenic Score (PGS) ID: PGS004897

Predicted Trait
Reported Trait Urinary albumin-to-creatinine ratio
Mapped Trait(s) urinary albumin to creatinine ratio (EFO_0007778)
Released in PGS Catalog: May 8, 2024
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Score Details

Score Construction
PGS Name UACR
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 28
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000623
Citation (link to publication) Cañadas-Garre M et al. Int J Mol Sci (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
264,018 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 26631737
 67,452 individuals European ADVANCE_TRIAL
Europe PMC: 21355061
 63,153 individuals European CARDIA, CKDGen, MESA
GWAS Catalog: GCST003372
Europe PMC: 26831199
 133,413 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021278 PSS011675|
European Ancestry|
389,206 individuals
 PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
 Reported Trait: Microalbuminuria OR: 1.045 [1.003, 1.089] — R²: 0.028 Age, sex, BMI, anti-hypertensive medication, cholesterol medication, diabetes, smoking history, insulin —
PPM021279 PSS011675|
European Ancestry|
389,206 individuals
 PGP000623 |
Cañadas-Garre M et al. Int J Mol Sci (2023)
 Reported Trait: Urinary albumin-to-creatinine ratio β: 0.015 (0.004) — R²: 0.093 Age, sex, BMI, anti-hypertensive medication, cholesterol medication, diabetes, smoking history, insulin —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011675 — — 389,206 individuals,
46.1 % Male samples
 Mean = 56.9 years
Sd = 8.0 years		 European — UKB —