| Predicted Trait | |
| Reported Trait | Spontaneous coronary artery dissection |
| Mapped Trait(s) | spontaneous coronary artery dissection (EFO_0010820) |
| Score Construction | |
| PGS Name | PRS_SCAD |
| Development Method | |
| Name | LD-pruning |
| Parameters | FDR q value < 0.05, r^2 > 0.2 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 7 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000629 |
| Citation (link to publication) | Saw J et al. Nat Commun (2020) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | |
| PGS Evaluation | European: 75% Not Reported: 25% 4 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST90000582 Europe PMC: 32887874 |
5,533 individuals | East Asian, European | MGI, canSCAD |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM021316 | PSS011682| Ancestry Not Reported| 412 individuals |
PGP000629 | Saw J et al. Nat Commun (2020) |
Reported Trait: Spontaneous coronary artery dissection | OR: 1.82 [1.09, 3.02] β: 0.597 (0.259) |
— | — | Age, sex | — |
| PPM021317 | PSS011685| European Ancestry| 373,056 individuals |
PGP000629 | Saw J et al. Nat Commun (2020) |
Reported Trait: Myocardial infarction | HR: 0.91 [0.89, 0.93] β: -0.094 (0.011) |
— | — | Age, sex, genotyping array and batch, PCs (1-4) | — |
| PPM021318 | PSS011685| European Ancestry| 373,056 individuals |
PGP000629 | Saw J et al. Nat Commun (2020) |
Reported Trait: Myocardial infarction in males | HR: 0.91 [0.89, 0.93] β: -0.092 (0.013) |
— | — | Age, genotyping array and batch, PCs (1-4) | — |
| PPM021319 | PSS011685| European Ancestry| 373,056 individuals |
PGP000629 | Saw J et al. Nat Commun (2020) |
Reported Trait: Myocaridal infarction in females | HR: 0.91 [0.87, 0.95] β: -0.099 (0.022) |
— | — | Age, genotyping array and batch, PCs (1-4) | — |
| PPM021320 | PSS011683| European Ancestry| 294,465 individuals |
PGP000629 | Saw J et al. Nat Commun (2020) |
Reported Trait: Coronary artery disease | β: -0.05 (0.004) OR: 0.95 [0.94, 0.96] |
— | — | Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), sex, PCs(1-10) | — |
| PPM021321 | PSS011683| European Ancestry| 294,465 individuals |
PGP000629 | Saw J et al. Nat Commun (2020) |
Reported Trait: Coronary artery disease in males | OR: 0.95 [0.94, 0.96] β: -0.05 (0.004) |
— | — | Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), PCs(1-10) | — |
| PPM021322 | PSS011684| European Ancestry| 314,434 individuals |
PGP000629 | Saw J et al. Nat Commun (2020) |
Reported Trait: Myocardial infarction | OR: 0.96 [0.95, 0.98] β: -0.04 (0.009) |
— | — | Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), sex, PCs(1-10) | — |
| PPM021323 | PSS011684| European Ancestry| 314,434 individuals |
PGP000629 | Saw J et al. Nat Commun (2020) |
Reported Trait: Myocardial infarction in males | OR: 0.96 [0.95, 0.98] β: -0.039 (0.009) |
— | — | Age (at the time of event in cases and at the time of last VA visit prior to August 2018 for controls), PCs(1-10) | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011685 | MI events were defined pre- enrollment by self-reported medical history and post-enrollment by hospital epi- sode statistics using ICD, Version 10 diagnosis codes (I21, I22, I23, or I24). Events were censored on the date of loss to follow-up, death, or if individuals remained event free up to March 31, 2017. | — | [ ,
45.86 % Male samples |
— | European | — | UKB | — |
| PSS011682 | All individuals had multifocal FMD. Cases show those with spontaneous coronary artery dissection. | — | [
|
— | Not reported | — | CCGB | Cases from Cleveland Clinic FMD Biorepository |
| PSS011683 | An individual was classified as a case if he or she had ≥1 admission to a VA hospital with discharge diagnosis of acute myocardial infarction (AMI) or ≥1 procedure code for revascularization of the coronary arteries or ≥2 ICD codes for CAD (410-414) on ≥2 dates. | — | [
|
— | European | — | MVP | — |
| PSS011684 | Cases are individuals with evidence of hospitilisation for myocardial infarction. | — | [
|
— | European | — | MVP | — |