Polygenic Score (PGS) ID: PGS004915

Predicted Trait
Reported Trait LDL cholesterol
Mapped Trait(s) low density lipoprotein cholesterol measurement (EFO_0004611)
Released in PGS Catalog: June 12, 2024
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Score Details

Score Construction
PGS Name LDL-C_PGS
Development Method
Name Previously associated SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 223
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000647
Citation (link to publication) Trinder M et al. Arterioscler Thromb Vasc Biol (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 72.4%
African: 19.3%
Hispanic or Latin American: 8.3%
297,626 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006612
Europe PMC: 30275531
 215,551 individuals European MVP
GWAS Catalog: GCST006612
Europe PMC: 30275531
 57,332 individuals African American or Afro-Caribbean MVP
GWAS Catalog: GCST006612
Europe PMC: 30275531
 24,743 individuals Hispanic or Latin American MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021380 PSS011715|
European Ancestry|
389,564 individuals
 PGP000647 |
Trinder M et al. Arterioscler Thromb Vasc Biol (2019)
 Reported Trait: Low-density lipoprotein cholesterol levels — — R²: 0.05 Age, sex, genotyping array/batch, 4 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011715 — — 389,564 individuals,
46.0 % Male samples
 Mean = 57.0 years European
(British)		 — UKB —