Polygenic Score (PGS) ID: PGS004962

Predicted Trait
Reported Trait Hemoglobin
Mapped Trait(s) hemoglobin measurement (EFO_0004509)
Released in PGS Catalog: Oct. 8, 2024
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Score Details

Score Construction
PGS Name Hemoglobin_Mean_INT_prscs_AFRss_afrld
Development Method
Name prscs
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,273,252
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000679
Citation (link to publication) Gunn S et al. HGG Adv (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 50.3%
  • European
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
European: 35.7%
African: 9.9%
Hispanic or Latin American: 4.1%
1,160,903 individuals (100%)
PGS Evaluation
African: 33.3%
Hispanic or Latin American: 33.3%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 114,793 individuals African American or Afro-Caribbean MVP
— 414,403 individuals European MVP
— 47,733 individuals Hispanic or Latin American MVP
— 583,974 individuals European, African American or Afro-Caribbean, Hispanic or Latin American, Asian unspecified MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021975 PSS011815|
European Ancestry|
28,828 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Hemoglobin β: 0.044 [0.03, 0.05] — R²: 0.002 score previously adjusted for age, sex, 20 PCs —
PPM021982 PSS011795|
African Ancestry|
8,793 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Hemoglobin β: 0.065 [0.05, 0.08] — R²: 0.005 score previously adjusted for age, sex, 20 PCs —
PPM021989 PSS011805|
Hispanic or Latin American Ancestry|
6,376 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Hemoglobin β: 0.048 [0.02, 0.07] — R²: 0.003 score previously adjusted for age, sex, 20 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011795 — — 8,793 individuals — African American or Afro-Caribbean — AllofUs —
PSS011805 — — 6,376 individuals — Hispanic or Latin American — AllofUs —
PSS011815 — — 28,828 individuals — European — AllofUs —