Polygenic Score (PGS) ID: PGS004967

Predicted Trait
Reported Trait Hemoglobin
Mapped Trait(s) hemoglobin measurement (EFO_0004509)
Released in PGS Catalog: Oct. 8, 2024
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Score Details

Score Construction
PGS Name Hemoglobin_Mean_INT_prscs_METAss_eurld
Development Method
Name prscs
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,273,252
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000679
Citation (link to publication) Gunn S et al. HGG Adv (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 50.3%
  • European
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
European: 35.7%
African: 9.9%
Hispanic or Latin American: 4.1%
1,160,903 individuals (100%)
PGS Evaluation
African: 33.3%
Hispanic or Latin American: 33.3%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
114,793 individuals African American or Afro-Caribbean MVP
414,403 individuals European MVP
47,733 individuals Hispanic or Latin American MVP
583,974 individuals European, African American or Afro-Caribbean, Hispanic or Latin American, Asian unspecified MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021974 PSS011815|
European Ancestry|
28,828 individuals
PGP000679 |
Gunn S et al. HGG Adv (2024)
Reported Trait: Hemoglobin β: 0.135 [0.12, 0.15] : 0.021 score previously adjusted for age, sex, 20 PCs
PPM021981 PSS011795|
African Ancestry|
8,793 individuals
PGP000679 |
Gunn S et al. HGG Adv (2024)
Reported Trait: Hemoglobin β: 0.081 [0.06, 0.1] : 0.007 score previously adjusted for age, sex, 20 PCs
PPM021988 PSS011805|
Hispanic or Latin American Ancestry|
6,376 individuals
PGP000679 |
Gunn S et al. HGG Adv (2024)
Reported Trait: Hemoglobin β: 0.086 [0.06, 0.11] : 0.009 score previously adjusted for age, sex, 20 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011795 8,793 individuals African American or Afro-Caribbean AllofUs
PSS011805 6,376 individuals Hispanic or Latin American AllofUs
PSS011815 28,828 individuals European AllofUs