Polygenic Score (PGS) ID: PGS004994

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: Oct. 8, 2024
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Score Details

Score Construction
PGS Name mean_BMI_INT_prscsx_METAweight
Development Method
Name prscsx
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,277,825
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000679
Citation (link to publication) Gunn S et al. HGG Adv (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 50.3%
  • European
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
European: 35.7%
African: 9.9%
Hispanic or Latin American: 4.1%
1,205,892 individuals (100%)
PGS Evaluation
African: 33.3%
Hispanic or Latin American: 33.3%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 118,817 individuals African American or Afro-Caribbean MVP
— 430,960 individuals European MVP
— 49,409 individuals Hispanic or Latin American MVP
— 606,706 individuals European, African American or Afro-Caribbean, Hispanic or Latin American, Asian unspecified MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022013 PSS011822|
European Ancestry|
44,889 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Body mass index (BMI) β: 0.33 [0.32, 0.34] — R²: 0.11 score previously adjusted for age, sex, 20 PCs —
PPM022020 PSS011802|
African Ancestry|
19,059 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Body mass index (BMI) β: 0.222 [0.21, 0.24] — R²: 0.055 score previously adjusted for age, sex, 20 PCs —
PPM022027 PSS011812|
Hispanic or Latin American Ancestry|
12,857 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Body mass index (BMI) β: 0.32 [0.3, 0.34] — R²: 0.105 score previously adjusted for age, sex, 20 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011802 — — 19,059 individuals — African American or Afro-Caribbean — AllofUs —
PSS011812 — — 12,857 individuals — Hispanic or Latin American — AllofUs —
PSS011822 — — 44,889 individuals — European — AllofUs —