Polygenic Score (PGS) ID: PGS005000

Predicted Trait
Reported Trait Height
Mapped Trait(s) body height (EFO_0004339)
Released in PGS Catalog: Oct. 8, 2024
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Score Details

Score Construction
PGS Name mean_Height_INT_ldpred_METAss_eurld
Development Method
Name ldpred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,286,612
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000679
Citation (link to publication) Gunn S et al. HGG Adv (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 50.3%
  • European
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
European: 35.7%
African: 9.9%
Hispanic or Latin American: 4.1%
1,206,130 individuals (100%)
PGS Evaluation
African: 33.3%
Hispanic or Latin American: 33.3%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 118,836 individuals African American or Afro-Caribbean MVP
— 431,043 individuals European MVP
— 49,426 individuals Hispanic or Latin American MVP
— 606,825 individuals European, African American or Afro-Caribbean, Hispanic or Latin American, Asian unspecified MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022132 PSS011823|
European Ancestry|
45,413 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Height β: 0.328 [0.32, 0.33] — R²: 0.202 score previously adjusted for age, sex, 20 PCs —
PPM022138 PSS011803|
African Ancestry|
19,353 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Height β: 0.216 [0.21, 0.23] — R²: 0.079 score previously adjusted for age, sex, 20 PCs —
PPM022144 PSS011813|
Hispanic or Latin American Ancestry|
13,065 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Height β: 0.253 [0.24, 0.26] — R²: 0.125 score previously adjusted for age, sex, 20 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011803 — — 19,353 individuals — African American or Afro-Caribbean — AllofUs —
PSS011813 — — 13,065 individuals — Hispanic or Latin American — AllofUs —
PSS011823 — — 45,413 individuals — European — AllofUs —