Polygenic Score (PGS) ID: PGS005042

Predicted Trait
Reported Trait Myocardial infarction (PheCode 411.2)
Mapped Trait(s) myocardial infarction (EFO_0000612)
Released in PGS Catalog: Oct. 8, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name Phe_411_2_prscs_HISss_amrld
Development Method
Name prscs
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,273,897
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000679
Citation (link to publication) Gunn S et al. HGG Adv (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 50.3%
European: 36%
African: 9.6%
Hispanic or Latin American: 4.1%
1,219,181 individuals (100%)
PGS Evaluation
African: 33.3%
Hispanic or Latin American: 33.3%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
—
[
  • 7,836 cases
  • , 109,218 controls
]
African American or Afro-CaribbeanMVP
—
[
  • 39,613 cases
  • , 399,292 controls
]
EuropeanMVP
—
[
  • 2,989 cases
  • , 46,689 controls
]
Hispanic or Latin AmericanMVP
—
[
  • 50,758 cases
  • , 562,786 controls
]
Not reportedMVP
Showing 1 to 4 of 4 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM021801PSS011808|
Hispanic or Latin American Ancestry|
8,047 individuals
PGP000679 |
Gunn S et al. HGG Adv (2024)
Reported Trait: Myocardial infarctionOR: 1.194 [1.03, 1.38]C-index: 0.82033—age, sex, 20 PCs—
PPM021808PSS011818|
European Ancestry|
30,379 individuals
PGP000679 |
Gunn S et al. HGG Adv (2024)
Reported Trait: Myocardial infarctionOR: 1.122 [1.07, 1.18]C-index: 0.76923—age, sex, 20 PCs—
PPM021815PSS011798|
African Ancestry|
10,479 individuals
PGP000679 |
Gunn S et al. HGG Adv (2024)
Reported Trait: Myocardial infarctionOR: 1.036 [0.94, 1.14]C-index: 0.73253—age, sex, 20 PCs—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011798——
[
  • 539 cases
  • , 9,940 controls
]
—African American or Afro-Caribbean—AllofUs—
PSS011808——
[
  • 304 cases
  • , 7,743 controls
]
—Hispanic or Latin American—AllofUs—
PSS011818——
[
  • 1,783 cases
  • , 28,596 controls
]
—European—AllofUs—
Showing 1 to 3 of 3 rows