Polygenic Score (PGS) ID: PGS005095

Predicted Trait
Reported Trait WHR adjusted for BMI
Mapped Trait(s) BMI-adjusted waist-hip ratio (EFO_0007788)
Released in PGS Catalog: Oct. 29, 2024
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Score Details

Score Construction
PGS Name WHRadjBMI_GRS
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-08, imputation score >0.7
Variants
Original Genome Build NR
Number of Variants 481
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000686
Citation (link to publication) Christiansen MR et al. Diabetes (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
694,649 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Hispanic or Latin American
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008999
Europe PMC: 30239722
 694,649 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022186 PSS011834|
Multi-ancestry (including European)|
1,415 individuals
 PGP000686 |
Christiansen MR et al. Diabetes (2023)
 Reported Trait: Waist circumference change following weight loss (year 1 to year 2) β: 0.033 (0.01) — — Intervention arm, sex, baseline age, 4 PCs, baseline weight, baseline height, baseline WC, year-1 weight and waist circumference, year-2 weight —
PPM022187 PSS011834|
Multi-ancestry (including European)|
1,415 individuals
 PGP000686 |
Christiansen MR et al. Diabetes (2023)
 Reported Trait: Waist circumference change following weight loss (year 1 to year 4) β: 0.026 (0.01) — — Intervention arm, sex, baseline age, 4 PCs, baseline weight, baseline height, baseline WC, year-1 weight and waist circumference, year-4 weight —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011834 — — 952 individuals — European — Look AHEAD —
PSS011834 — — 187 individuals — African unspecified — Look AHEAD —
PSS011834 — — 233 individuals — Hispanic or Latin American — Look AHEAD —
PSS011834 — — 43 individuals — Not reported — Look AHEAD —