Predicted Trait | |
Reported Trait | Prostate specific antigen |
Mapped Trait(s) | prostate specific antigen amount (OBA_2050200) |
Additional Trait Information | log(PSA) in men without prostate cancer |
Score Construction | |
PGS Name | psa2024_prs_447 |
Development Method | |
Name | mJam |
Parameters | P<5e-8, r2<0.01, Independent from mJam |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 447 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000692 |
Citation (link to publication) | Hoffmann TJ et al. Nat Genet (2025) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
GWAS Catalog: GCST90461907 Europe PMC: 39930085 |
61,745 individuals | African unspecified | 12 cohorts
|
— | — | — | — | — |
GWAS Catalog: GCST90461907 Europe PMC: 39930085 |
6,967 individuals | Asian unspecified | 12 cohorts
|
— | — | — | — | — |
GWAS Catalog: GCST90461907 Europe PMC: 39930085 |
297,166 individuals | European | 12 cohorts
|
— | — | — | — | — |
GWAS Catalog: GCST90461907 Europe PMC: 39930085 |
26,644 individuals | Hispanic or Latin American | 12 cohorts
|
— | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM022209 | PSS011850| European Ancestry| 22,173 individuals |
PGP000692 | Hoffmann TJ et al. Nat Genet (2025) |
Reported Trait: log(PSA) | — | — | Partial R2: 0.109 | age, ancestry pcs | Partial r2: variation explained by the PGS only, but derived from a fully adjusted model that includes listed covariates |
PPM022213 | PSS011848| African Ancestry| 1,173 individuals |
PGP000692 | Hoffmann TJ et al. Nat Genet (2025) |
Reported Trait: log(PSA) | — | — | Partial R2: 0.07 | age, ancestry pcs | Partial r2: variation explained by the PGS only, but derived from a fully adjusted model that includes listed covariates |
PPM022217 | PSS011849| Additional Asian Ancestries| 257 individuals |
PGP000692 | Hoffmann TJ et al. Nat Genet (2025) |
Reported Trait: log(PSA) | — | — | Partial R2: 0.035 | age, ancestry pcs | Partial r2: variation explained by the PGS only, but derived from a fully adjusted model that includes listed covariates |
PPM022221 | PSS011846| European Ancestry| 11,922 individuals |
PGP000692 | Hoffmann TJ et al. Nat Genet (2025) |
Reported Trait: log(PSA) | — | — | Partial R2: 0.113 | age, ancestry pcs | Partial r2: variation explained by the PGS only, but derived from a fully adjusted model that includes listed covariates |
PPM022225 | PSS011844| African Ancestry| 2,469 individuals |
PGP000692 | Hoffmann TJ et al. Nat Genet (2025) |
Reported Trait: log(PSA) | — | — | Partial R2: 0.053 | age, ancestry pcs | Partial r2: variation explained by the PGS only, but derived from a fully adjusted model that includes listed covariates |
PPM022229 | PSS011847| Additional Diverse Ancestries| 1,783 individuals |
PGP000692 | Hoffmann TJ et al. Nat Genet (2025) |
Reported Trait: log(PSA) | — | — | Partial R2: 0.086 | age, ancestry pcs | Partial r2: variation explained by the PGS only, but derived from a fully adjusted model that includes listed covariates |
PPM022233 | PSS011845| Hispanic or Latin American Ancestry| 1,336 individuals |
PGP000692 | Hoffmann TJ et al. Nat Genet (2025) |
Reported Trait: log(PSA) | — | — | Partial R2: 0.096 | age, ancestry pcs | Partial r2: variation explained by the PGS only, but derived from a fully adjusted model that includes listed covariates |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011844 | Prostate specific antigen | — | 2,469 individuals, 100.0 % Male samples |
— | African unspecified | — | AllofUs | — |
PSS011845 | Prostate specific antigen | — | 1,336 individuals, 100.0 % Male samples |
— | Hispanic or Latin American | — | AllofUs | — |
PSS011846 | Prostate specific antigen | — | 11,922 individuals, 100.0 % Male samples |
— | European | — | AllofUs | — |
PSS011847 | Prostate specific antigen | — | 1,783 individuals, 100.0 % Male samples |
— | Other | — | AllofUs | — |
PSS011848 | Prostate specific antigen | — | 1,173 individuals, 100.0 % Male samples |
— | African unspecified | — | SELECT | — |
PSS011849 | Prostate specific antigen | — | 257 individuals, 100.0 % Male samples |
— | Asian unspecified | — | SELECT | — |
PSS011850 | Prostate specific antigen | — | 22,173 individuals, 100.0 % Male samples |
— | European | — | SELECT | — |