Predicted Trait | |
Reported Trait | Body mass index (BMI) |
Mapped Trait(s) | body mass index (EFO_0004340) |
Score Construction | |
PGS Name | PGS_BMI |
Development Method | |
Name | PRS-CSx |
Parameters | PHI=AUTO |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 1,022,364 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000701 |
Citation (link to publication) | Loesch DP et al. medRxiv (2024) Preprint |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | European: 59.6% East Asian: 39.8% Hispanic or Latin American: 0.3% African: 0.2% 397,228 individuals (100%) |
PGS Evaluation |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST002783 Europe PMC: 25673413 |
236,781 individuals | European | GIANT |
GWAS Catalog: GCST002783 Europe PMC: 25673413 |
887 individuals | African American or Afro-Caribbean | GIANT |
GWAS Catalog: GCST002783 Europe PMC: 25673413 |
1,276 individuals | Hispanic or Latin American | GIANT |
GWAS Catalog: GCST004904 Europe PMC: 28892062 |
158,284 individuals | East Asian | BBJ |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM022305 | PSS011911| Multi-ancestry (including European)| 48,603 individuals |
PGP000701 | Loesch DP et al. medRxiv (2024) |Pre |
Reported Trait: body mass index | β: 1.32 [1.28, 1.36] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
PPM022316 | PSS011912| European Ancestry| 45,356 individuals |
PGP000701 | Loesch DP et al. medRxiv (2024) |Pre |
Reported Trait: body mass index | β: 1.34 [1.3, 1.39] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011911 | ICD10: E11 for T2D, N18 for CKD, first occurence of I20-125 for CAD. BMI: baseline body mass index | Median = 14.8 years | 48,603 individuals, 46.0 % Male samples |
Mean = 56.8 years Sd = 8.2 years |
European, East Asian, South Asian, Hispanic or Latin American, African unspecified | — | UKB | — |
PSS011912 | ICD10: E11 for T2D, N18 for CKD, first occurence of I20-125 for CAD, K76.0 for NAFLD. BMI: baseline body mass index | Median = 14.8 years | 45,356 individuals, 46.0 % Male samples |
Mean = 57.1 years Sd = 8.1 years |
European | — | UKB | — |