Predicted Trait | |
Reported Trait | Esophageal cancer |
Mapped Trait(s) | esophageal carcinoma (EFO_0002916) |
Score Construction | |
PGS Name | PRS-ESC |
Development Method | |
Name | Known susceptibility loci (genome-wide significant SNPs) |
Parameters | LD r2 > 0.2 ; SNP threshold < 5×10^-8 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 11 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000711 |
Citation (link to publication) | Zhu M et al. PLoS Med (2025) |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | East Asian: 100% 11,124 individuals (100%) |
PGS Evaluation | East Asian: 100% 1 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST002568 Europe PMC: 25129146 |
11,124 individuals | East Asian | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM022397 | PSS011937| East Asian Ancestry| 100,219 individuals |
PGP000711 | Zhu M et al. PLoS Med (2025) |
Reported Trait: Esophageal Cancer | HR: 1.26 [1.16, 1.38] β: 0.246 |
C-index: 0.559 | — | Age,Sex (if applicable),Region,Top 10 genetic ancestry principal components | The HR and C-index values were derived from Cox proportional hazards regression models. |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011937 | ICD-10: C15 | Median = 11.33 years Range = [10.18, 12.26] years |
[ ,
42.8 % Male samples |
Mean = 53.69 years Sd = 11.01 years |
East Asian (Chinese) |
— | CKB | — |