Polygenic Score (PGS) ID: PGS005163

Predicted Trait
Reported Trait Lung cancer
Mapped Trait(s) lung carcinoma (EFO_0001071)
Released in PGS Catalog: March 17, 2025
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS-LC
Development Method
Name Known susceptibility loci (genome-wide significant SNPs)
Parameters LD r2 ＞ 0.2 ; SNP threshold ＜ 5×10^-8
Variants
Original Genome Build GRCh37
Number of Variants 42
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000711
Citation (link to publication) Zhu M et al. PLoS Med (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 90.6%
European: 9.4%
221,662 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST008836
Europe PMC: 31326317
22,090 individualsEast AsianNR
GWAS Catalog: GCST008836
Europe PMC: 31326317
20,846 individualsEuropeanNR
GWAS Catalog: GCST90018655
Europe PMC: 34594039
178,726 individualsEast AsianBBJ
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM022401PSS011939|
East Asian Ancestry|
100,219 individuals
PGP000711 |
Zhu M et al. PLoS Med (2025)
Reported Trait: Lung CancerHR: 1.22 [1.16, 1.28]
β: 0.199		C-index: 0.55—Age,Sex (if applicable),Region,Top 10 genetic ancestry principal componentsThe HR and C-index values were derived from Cox proportional hazards regression models.
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011939ICD-10: C33-34Median = 11.33 years
Range = [10.18, 12.26] years
[
  • 1,540 cases
  • , 98,679 controls
]
,
42.8 % Male samples
Mean = 53.69 years
Sd = 11.01 years		East Asian
(Chinese)		—CKB—
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