PGS Publication: PGP000510

Publication Information (EuropePMC)
Title Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
PubMed ID 37268629(Europe PMC)
doi 10.1038/s41467-023-38990-9
Publication Date June 2, 2023
Journal Nat Commun
Author(s) Kurniansyah N, Goodman MO, Khan AT, Wang J, Feofanova E, Bis JC, Wiggins KL, Huffman JE, Kelly T, Elfassy T, Guo X, Palmas W, Lin HJ, Hwang SJ, Gao Y, Young K, Kinney GL, Smith JA, Yu B, Liu S, Wassertheil-Smoller S, Manson JE, Zhu X, Chen YI, Lee IT, Gu CC, Lloyd-Jones DM, Zöllner S, Fornage M, Kooperberg C, Correa A, Psaty BM, Arnett DK, Isasi CR, Rich SS, Kaplan RC, Redline S, Mitchell BD, Franceschini N, Levy D, Rotter JI, Morrison AC, Sofer T.
Released in PGS Catalog: Oct. 17, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003962
(DBP_EAS)
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Diastolic blood pressure diastolic blood pressure 978,280
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003962/ScoringFiles/PGS003962.txt.gz
PGS003965
(SBP_AFR)
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Systolic blood pressure systolic blood pressure 1,221,464
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003965/ScoringFiles/PGS003965.txt.gz
PGS003967
(SBP_EUR)
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Systolic blood pressure systolic blood pressure 1,108,368
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003967/ScoringFiles/PGS003967.txt.gz
PGS003961
(DBP_AFR)
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Diastolic blood pressure diastolic blood pressure 1,221,464
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003961/ScoringFiles/PGS003961.txt.gz
PGS003963
(DBP_EUR)
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Diastolic blood pressure diastolic blood pressure 1,110,130
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003963/ScoringFiles/PGS003963.txt.gz
PGS003966
(SBP_EAS)
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Systolic blood pressure systolic blood pressure 978,280
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003966/ScoringFiles/PGS003966.txt.gz
PGS003968
(SBP_weightedPRSsum)
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Systolic blood pressure systolic blood pressure 1,267,240
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003968/ScoringFiles/PGS003968.txt.gz
PGS003964
(DBP_weightedPRSsum)
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Diastolic blood pressure diastolic blood pressure 1,267,600
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003964/ScoringFiles/PGS003964.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019122 PGS003964
(DBP_weightedPRSsum)
 PSS011189|
Multi-ancestry (including European)|
88,521 individuals
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Reported Trait: Diastolic blood pressure β: 2.41 [2.31, 2.5] — — age, sex at birth, BMI, self-reported race/ethnicity, and the first 10 PCs of genetic data best performing DBP PRSs as selected in the TOPMed dataset (PRS-CSx2)
PPM019121 PGS003968
(SBP_weightedPRSsum)
 PSS011189|
Multi-ancestry (including European)|
88,521 individuals
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Reported Trait: Systolic blood pressure β: 3.62 [3.47, 3.77] — — age, sex at birth, BMI, self-reported race/ethnicity, and the first 10 PCs of genetic data best performing SBP PRSs as selected in the TOPMed dataset (PRS-CSx2)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011189 — — 19,441 individuals,
44.7 % Male samples
 Mean = 47.36 years
Sd = 14.8 years		 African unspecified — AllofUs —
PSS011189 — — 2,891 individuals,
40.3 % Male samples
 Mean = 42.96 years
Sd = 16.67 years		 Asian unspecified — AllofUs —
PSS011189 — — 48,155 individuals,
40.4 % Male samples
 Mean = 53.65 years
Sd = 16.61 years		 European — AllofUs —
PSS011189 — — 18,034 individuals,
31.9 % Male samples
 Mean = 44.27 years
Sd = 15.79 years		 Hispanic or Latin American — AllofUs —