PGS Publication: PGP000590

Publication Information (EuropePMC)
Title Development and testing of a polygenic risk score for breast cancer aggressiveness.
PubMed ID 37188791(Europe PMC)
doi 10.1038/s41698-023-00382-z
Publication Date May 15, 2023
Journal NPJ Precis Oncol
Author(s) Shieh Y, Roger J, Yau C, Wolf DM, Hirst GL, Swigart LB, Huntsman S, Hu D, Nierenberg JL, Middha P, Heise RS, Shi Y, Kachuri L, Zhu Q, Yao S, Ambrosone CB, Kwan ML, Caan BJ, Witte JS, Kushi LH, 't Veer LV, Esserman LJ, Ziv E.
Released in PGS Catalog: Feb. 20, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004611
(RORP_PRS)
 PGP000590 |
Shieh Y et al. NPJ Precis Oncol (2023)
 Breast cancer breast carcinoma 76
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004611/ScoringFiles/PGS004611.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020786 PGS004611
(RORP_PRS)
 PSS011411|
Multi-ancestry (including European)|
10,196 individuals
 PGP000590 |
Shieh Y et al. NPJ Precis Oncol (2023)
 Reported Trait: Breast cancer-specific survival HR: 1.13 [1.06, 1.21] — — 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011411 — — 10,196 individuals,
0.0 % Male samples
 — European, Not reported — Pathways, UKB —